{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:53:59Z","timestamp":1792371239098,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T00:00:00Z","timestamp":1291334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune polyendocrine syndrome type 1 (APS\u20101) is a multiorgan autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal failure are hallmarks of the disease. The critical mechanisms causing chronic mucocutaneous candidiasis in APS\u20101 patients have not been identified although autoantibodies to cytokines are implicated in the pathogenesis. To investigate whether the Th reactivity to <jats:italic>Candida albicans<\/jats:italic> (<jats:italic>C. albicans<\/jats:italic>) and other stimuli was altered, we isolated PBMC from APS\u20101 patients and matched healthy controls. The Th17 pathway was upregulated in response to <jats:italic>C. albicans<\/jats:italic> in APS\u20101 patients, whereas the IL\u201022 secretion was reduced. Autoantibodies against IL\u201022, IL\u201017A and IL\u201017F were detected in sera from APS\u20101 patients by immunoprecipitation. In addition, Aire\u2010deficient (Aire<jats:sup>0\/0<\/jats:sup>) mice were much more susceptible than Aire<jats:sup>+\/+<\/jats:sup> mice to mucosal candidiasis and <jats:italic>C. albicans<\/jats:italic>\u2010induced Th17\u2010 and Th1\u2010cell responses were increased in Aire<jats:sup>0\/0<\/jats:sup> mice. Thus an excessive IL\u201017A reactivity towards <jats:italic>C. albicans<\/jats:italic> was observed in APS\u20101 patients and Aire<jats:sup>0\/0<\/jats:sup> mice.<\/jats:p>","DOI":"10.1002\/eji.200939883","type":"journal-article","created":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T00:56:11Z","timestamp":1288832171000},"page":"235-245","source":"Crossref","is-referenced-by-count":40,"title":["Increased IL\u201017A secretion in response to <i>Candida albicans<\/i> in autoimmune polyendocrine syndrome type 1 and its animal model"],"prefix":"10.1002","volume":"41","author":[{"given":"Kerstin M.","family":"Ahlgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brita Ardesj\u00f6","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"\u00c5hlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Norling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Hallgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Perheentupa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Rorsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline E.","family":"Crewther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"R\u00f6nnelid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bensing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamish S.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"K\u00e4mpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina","family":"Romani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lobell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006283222601"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706487"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.1976"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02093.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159407"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.07.005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091669"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091983"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081463"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737409"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200839102"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080218"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06764"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838811"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.22"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1610"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1613"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081438"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(84)90450-2"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02090.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.07.002"},{"key":"e_1_2_6_24_2","first-page":"1","article-title":"Cell mediated immunity to fungi: a reassessment","volume":"12","author":"Romani L.","year":"2008","journal-title":"Med. 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