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However, its <jats:italic>in vivo<\/jats:italic> function has remained practically unknown and this work addresses those unknown aspects. We demonstrate using <jats:italic>in vivo<\/jats:italic> models that Clever\u20101\/Stabilin\u20101 mediates migration of T and B lymphocytes to the draining lymph nodes <jats:italic>in vivo<\/jats:italic> and identify the adhesive epitope of the Clever\u20101\/Stabilin\u20101 molecule responsible for the interaction between lymphocytes and lymphatic endothelium. Moreover, we demonstrate that Ab blocking of Clever\u20101\/Stabilin\u20101 efficiently inhibits peritonitis in mice by decreasing the entrance of granulocytes by 50%, while migration of monocytes and lymphocytes into the inflamed peritoneum is prevented almost completely. Despite efficient anti\u2010inflammatory activity the Ab therapy does not dramatically dampen immune responses against the bacterial and foreign protein Ag tested and bacterial clearance. These results indicate that anti\u2010Clever\u20101\/Stabilin\u20101 treatment can target two different arms of the vasculature \u2013 traffic <jats:italic>via<\/jats:italic> lymphatics and inflamed blood vessels.<\/jats:p>","DOI":"10.1002\/eji.200939896","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T17:53:49Z","timestamp":1255542829000},"page":"3477-3487","source":"Crossref","is-referenced-by-count":92,"title":["Clever\u20101\/Stabilin\u20101 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation"],"prefix":"10.1002","volume":"39","author":[{"given":"Marika","family":"Karikoski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Irjala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Maksimow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Miiluniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Granfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Hernesniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Elima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Moldenhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Schledzewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kzhyshkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergij","family":"Goerdt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Salmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirpa","family":"Jalkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1222"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1705"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.05.003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204277200"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00425.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.6.1425"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323859"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1921"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406897200"},{"key":"e_1_2_6_12_2","first-page":"4671","article-title":"Mannose 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