{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:42:30Z","timestamp":1790167350353,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The initiation of CD8<jats:sup>+<\/jats:sup> T cell (CTL) immune responses can occur <jats:italic>via<\/jats:italic> cross\u2010priming. Recent data suggested a relationship between cross\u2010presentation and immunodominance of epitope\u2010specific T cells. To test this association, we evaluated the efficacy of cross\u2010presentation for several virus epitopes <jats:italic>in vitro<\/jats:italic> and examined if this can be extrapolated <jats:italic>in vivo<\/jats:italic>. Employing lymphocytic choriomeningitis virus (LCMV), we demonstrate that the cross\u2010presentation and cross\u2010priming of LCMV antigens were dominated by NP396, but not NP205 when analyzing the LCMV\u2010NP. Although with LCMV\u2010GP, cross\u2010presentation was dominated by GP276, and cross\u2010priming was dominated by GP33. Importantly, although NP396 was significantly more efficient than GP33 in cross\u2010presentation, cross\u2010priming of their specific CTL was comparable. In a subsequent virus challenge after cross\u2010priming, GP33\u2010specific CTL dominated the response. Accordingly, based on our data, the ability of viral epitopes to be cross\u2010presented <jats:italic>in vitro<\/jats:italic> does not entirely reflect what would occur in cross\u2010priming. Thus, weak cross\u2010presenting antigens may still cross\u2010prime an efficient CTL response depending on other <jats:italic>in vivo<\/jats:italic> elements such as the na\u00efve T\u2010cell precursor frequencies.<\/jats:p>","DOI":"10.1002\/eji.200939973","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T02:56:19Z","timestamp":1275447379000},"page":"2190-2199","source":"Crossref","is-referenced-by-count":8,"title":["The outcome of cross\u2010priming during virus infection is not directly linked to the ability of the antigen to be cross\u2010presented"],"prefix":"10.1002","volume":"40","author":[{"given":"Attiya","family":"Alatery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Tarrab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Lamarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh","family":"Basta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.8.1135"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.8.1143"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.4049\/jimmunol.147.9.2846","article-title":"Macrophages as accessory cells for class I MHC\u2010restricted immune responses","volume":"147","author":"Debrick J. 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