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IL\u201033 signals <jats:italic>via<\/jats:italic> a heterodimer composed of its receptor, IL\u20101 receptor\u2010like\u20101 (IL\u20101RL1), more commonly known as ST2L, and the IL\u20101R accessory protein. ST2L is expressed by endothelial cells, mast cells, basophils, Th2 cells, and DC. IL\u201033 has been associated with several immune\u2010mediated disorders, including asthma, arthritis, and inflammatory bowel disease. In contrast, there is evidence that IL\u201033 can inhibit atherosclerosis development. A report in this issue of the <jats:italic>European Journal of Immunology<\/jats:italic> reveals a novel function of IL\u201033: the ability to promote myeloid DC generation in murine BM cell cultures, by triggering GM\u2010CSF production by other BM cells, likely basophils. DC generated in the presence of IL\u201033 are maturation resistant, with only minimal T\u2010cell stimulatory ability, associated with comparatively high levels of programmed death receptor ligand expression. This commentary discusses several questions raised by these findings, and provides a basis for further evaluation of IL\u201033 and ST2L in regulation of APC generation and function in both innate and adaptive immunity.<\/jats:p>","DOI":"10.1002\/eji.200940026","type":"journal-article","created":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T21:09:43Z","timestamp":1256850583000},"page":"3292-3295","source":"Crossref","is-referenced-by-count":17,"title":["IL\u201033 broadens its repertoire to affect DC"],"prefix":"10.1002","volume":"39","author":[{"given":"H\u0113th R.","family":"Turnquist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus W.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606854104"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63631-0"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071868"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.03.003"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M901744200"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.007"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.07.018"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00624.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2551"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705939104"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.5.787"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.9.4866"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.6930"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(00)01611-X"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.7.895"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.6.1069"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-157818"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.62"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.026"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5981"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.82"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1050"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803067"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801898105"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4780"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901206106"},{"key":"e_1_2_4_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704916200"},{"key":"e_1_2_4_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30634"},{"key":"e_1_2_4_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900328"},{"key":"e_1_2_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939472"},{"key":"e_1_2_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2132"},{"key":"e_1_2_4_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxn060"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200940026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200940026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:54:21Z","timestamp":1697514861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200940026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1002\/eji.200940026"],"URL":"https:\/\/doi.org\/10.1002\/eji.200940026","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}