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The understanding of mechanisms underlying allergic diseases as well as those operating in non\u2010allergic healthy responses and allergen\u2010specific immunotherapy has experienced exciting advances over the past 15 years. Studies in healthy non\u2010atopic individuals and several clinical trials of allergen\u2010specific immunotherapy have demonstrated that the induction of a tolerant state in peripheral T cells represent a key step in healthy immune responses to allergens. Both naturally occurring thymus\u2010derived CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>FOXP3<jats:sup>+<\/jats:sup> Treg and inducible type 1 Treg inhibit the development of allergy <jats:italic>via<\/jats:italic> several mechanisms, including suppression of other effector Th1, Th2, Th17 cells; suppression of eosinophils, mast cells and basophils; Ab isotype change from IgE to IgG4; suppression of inflammatory DC; and suppression of inflammatory cell migration to tissues. The identification of the molecules involved in these processes will contribute to the development of more efficient and safer treatment modalities.<\/jats:p>","DOI":"10.1002\/eji.200940045","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T15:37:29Z","timestamp":1265816249000},"page":"1232-1240","source":"Crossref","is-referenced-by-count":328,"title":["Role of Treg in immune regulation of allergic diseases"],"prefix":"10.1002","volume":"40","author":[{"given":"Oscar","family":"Palomares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6rkem","family":"Yaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet K.","family":"Azkur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunc","family":"Akkoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcbeccel","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,29]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1934"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.9.4848"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032058"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.03.013"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2653"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2250"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080193"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200322919"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.030"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1084"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2660"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070406"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9199"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.019"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065544"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.016"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.12.1171"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4832"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1659"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.041"},{"key":"e_1_2_10_22_2","first-page":"3573","article-title":"Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling","volume":"119","author":"Eyerich S.","year":"2009","journal-title":"J. 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