{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:08:55Z","timestamp":1789517335372,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,9,6]],"date-time":"2010-09-06T00:00:00Z","timestamp":1283731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Host protection to helminth infection requires IL\u20104 receptor \u03b1 chain (IL\u20104R\u03b1) signalling and the establishment of finely regulated Th2 responses. In the current study, the role of IL\u20104R\u03b1\u2010responsive T cells in <jats:italic>Schistosoma mansoni<\/jats:italic> egg\u2010induced inflammation was investigated. Egg\u2010induced inflammation in IL\u20104R\u03b1\u2010responsive BALB\/c mice was accompanied with Th2\u2010biased responses, whereas T\u2010cell\u2010specific IL\u20104R\u03b1\u2010deficient BALB\/c mice (<jats:italic>iLck<jats:sup>cre<\/jats:sup>Il4ra<jats:sup>\u2212<\/jats:sup><jats:sup>\/lox<\/jats:sup><\/jats:italic>) developed Th1\u2010biased responses with heightened inflammation. The proportion of Foxp3<jats:sup>+<\/jats:sup> Treg in the draining LN of control mice did not correlate with the control of inflammation and was reduced in comparison to T\u2010cell\u2010specific IL\u20104R\u03b1\u2010deficient mice. This was due to IL\u20104\u2010mediated inhibition of CD4<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup> Treg conversion, demonstrated in adoptively transferred <jats:italic>Rag2<jats:sup>\u2212<\/jats:sup><jats:sup>\/<\/jats:sup><jats:sup>\u2212<\/jats:sup><\/jats:italic> mice. Interestingly, reduced footpad swelling in <jats:italic>Il4ra<jats:sup>\u2212<\/jats:sup><jats:sup>\/lox<\/jats:sup><\/jats:italic> mice was associated with the induction of IL\u20104 and IL\u201010\u2010secreting CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup>CD103<jats:sup>+<\/jats:sup>Foxp3<jats:sup>\u2212<\/jats:sup> cells, confirmed in <jats:italic>S. mansoni<\/jats:italic> infection studies. Transfer of IL\u20104R\u03b1\u2010responsive CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup>CD103<jats:sup>+<\/jats:sup> cells, but not CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>high<\/jats:sup> or CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup>CD103<jats:sup>\u2212<\/jats:sup> cells, controlled inflammation in <jats:italic>iLck<jats:sup>cre<\/jats:sup>Il4ra<jats:sup>\u2212<\/jats:sup><jats:sup>\/lox<\/jats:sup><\/jats:italic> mice. The control of inflammation depended on IL\u201010, as transferred CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup>CD103<jats:sup>+<\/jats:sup> cells from IL\u201010\u2010deficient mice were not able to effectively downregulate inflammation. Together, these results demonstrate that IL\u20104 signalling in T cells inhibits Foxp3<jats:sup>+<\/jats:sup> Treg <jats:italic>in vivo<\/jats:italic> and promotes CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup>CD103<jats:sup>+<\/jats:sup>Foxp3<jats:sup>\u2212<\/jats:sup> cells that control <jats:italic>S. mansoni<\/jats:italic> egg\u2010induced inflammation <jats:italic>via<\/jats:italic> IL\u201010.<\/jats:p>","DOI":"10.1002\/eji.200940075","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T21:47:50Z","timestamp":1281995270000},"page":"2837-2847","source":"Crossref","is-referenced-by-count":26,"title":["Control of <i>Schistosoma mansoni<\/i> egg\u2010induced inflammation by IL\u20104\u2010responsive CD4<sup>+<\/sup>CD25<sup>\u2212<\/sup>CD103<sup>+<\/sup>Foxp3<sup>\u2212<\/sup> cells is IL\u201010\u2010dependent"],"prefix":"10.1002","volume":"40","author":[{"given":"Benjamin","family":"Dewals","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Hoving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G. 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