{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:43Z","timestamp":1787068063948,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T00:00:00Z","timestamp":1285113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is recognised as the chief cause of chronic gastritis, ulcers and gastric cancer in humans. With increased incidence of treatment failure and antibiotic resistance, development of prophylactic or therapeutic vaccination is a desirable alternative. Although the results of vaccination studies in animal models have been promising, studies in human volunteers have revealed problems such as \u2018post\u2010immunisation gastritis\u2019 and comparatively poor responses to vaccine antigens. The focus of this study was to compare the gastric and systemic cellular immune responses induced by recombinant attenuated\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhimurium\u2010based vaccination in the C57BL\/6 model of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection. Analysis of lymphocyte populations in the gastric mucosa, blood, spleen, paragastric LN and MLN revealed that the effects of vaccination were largely confined to the parenchymal stomach rather than lymphoid organs. Vaccine\u2010induced protection was correlated with an augmented local recall response in the gastric mucosa, with increased proportions of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, neutrophils and reduced proportions of CD4\n                    <jats:sup>+<\/jats:sup>\n                    Treg. CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells isolated from the stomachs of vaccinated mice proliferated\n                    <jats:italic>ex vivo<\/jats:italic>\n                    in response to\n                    <jats:italic>H. pylori<\/jats:italic>\n                    antigen, and secreted Th1 cytokines, particularly IFN\u2010\u03b3. This detailed analysis of local gastric immune responses provides insight into the mechanism of vaccine\u2010induced protection.\n                  <\/jats:p>","DOI":"10.1002\/eji.200940219","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T17:47:58Z","timestamp":1281980878000},"page":"2778-2790","source":"Crossref","is-referenced-by-count":26,"title":["Local recall responses in the stomach involving reduced regulation and expanded help mediate vaccine\u2010induced protection against\n                    <i>Helicobacter pylori<\/i>\n                    in mice"],"prefix":"10.1002","volume":"40","author":[{"given":"Dorit","family":"Becher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Deutscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim R.","family":"Simpfendorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odilia L.","family":"Wijburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Pederson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Lew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Strugnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Walduck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00702.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00518.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.07.009"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.523"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2001.00977.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00246-7"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.6.3581-3590.2001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2005.06.005"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.008"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.054"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00391-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01427.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145839"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70004-0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1714-1721.2001"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145839"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1096\/fj.04-2321fje","article-title":"Transcription profiling analysis of the mechanisms of vaccine\u2010induced protection against H","volume":"18","author":"Walduck A.","year":"2004","journal-title":"pylori. 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