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ST2, a member of the IL\u20101R superfamily, is a secreted form of ST2 gene products, which has been shown to act as a decoy receptor for IL\u201033 and to inhibit the IL\u201033\/ST2L\/IL\u20101RAcP signaling pathway. In this work, we generated ST2 transgenic mice. In control mice, intraperitoneal administration of IL\u201033 caused an increased number of eosinophils in blood and in peritoneal cavity, an increased number of peritoneal M\u03a6, splenomegaly, accumulation of periodic acid\u2010Schiff\u2010positive material in the lung, and high concentrations of serum IL\u20105 and IL\u201013. However, these alterations were hardly detectable in ST2 Tg mice. In peritoneal M\u03a6 from IL\u201033\u2010stimulated mice, mRNA expression of M2 M\u03a6 marker genes were increased compared with thioglycollate\u2010elicited peritoneal M\u03a6. The IL\u201033\u2010stimulation also increased the secretion of IL\u20106 from M\u03a6. However, when the IL\u201033 was preincubated with ST2 prior to its addition to the M\u03a6 cultures, the secretion of IL\u20106 was attenuated. These data suggest that, though IL\u201033 induced the Th2\u2010type immune responses and infiltration of M2 type M\u03a6 into the peritoneal cavity, ST2 can downregulate these reactions both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.200940291","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T17:08:03Z","timestamp":1278695283000},"page":"2632-2642","source":"Crossref","is-referenced-by-count":35,"title":["Characterization of ST2 transgenic mice with resistance to 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