{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T14:34:14Z","timestamp":1720794854130},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T00:00:00Z","timestamp":1280448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease of hematopoietic stem cells. The disease progresses after several years from an initial chronic phase to a blast phase. Leukemia\u2010specific T cells are regularly detected in CML patients and may be involved in the immunological control of the disease. Here, we analyzed the role of leukemia\u2010specific CD8<jats:sup>+<\/jats:sup> T cells in CML disease control and the mechanism that maintains CD8<jats:sup>+<\/jats:sup> T\u2010cell immunosurveillance in a retroviral\u2010induced murine CML model. To study antigen\u2010specific immune responses, the glycoprotein of the lymphocytic choriomeningitis virus was used as model leukemia antigen. Leukemia\u2010specific CTL activity was detectable <jats:italic>in vivo<\/jats:italic> in CML mice and depletion of CD8<jats:sup>+<\/jats:sup> T cells rapidly led to disease progression. CML\u2010specific CTL were characterized by the expression of the IL\u20107 receptor \u03b1\u2010chain. In addition, leukemia cells produced IL\u20107 that was crucial for the maintenance of leukemia\u2010specific CTL and for disease control. Therefore, CML cells maintain the specific CD8<jats:sup>+<\/jats:sup> T\u2010cell\u2010mediated immune control by IL\u20107 secretion. This results in prolonged control of disease and probably contributes to the characteristic chronic phase of the disease.<\/jats:p>","DOI":"10.1002\/eji.201040404","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T14:38:23Z","timestamp":1280500703000},"page":"2720-2730","source":"Crossref","is-referenced-by-count":9,"title":["Chronic myelogenous leukemia maintains specific CD8<sup>+<\/sup> T cells through IL\u20107 signaling"],"prefix":"10.1002","volume":"40","author":[{"given":"Sabine","family":"Mumprecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Sch\u00fcrch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Scherrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Claus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian F.","family":"Ochsenbein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.10.3829"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1567"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402577"},{"key":"e_1_2_6_5_2","first-page":"53","article-title":"Bone marrow transplantation for patients with chronic myeloid leukaemia: T\u2010cell depletion with Campath\u20101 reduces the incidence of graft\u2010versus\u2010host disease but may increase the risk of leukaemic relapse","volume":"1","author":"Apperley J. 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