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In addition, caspase\u20101 activation leads to a certain type of cell death known as pyroptosis. Activation of the inflammasome has been shown to play a critical role in the recognition and containment of various microbial pathogens, including the intracellularly replicating <jats:italic>Listeria monocytogenes<\/jats:italic>; however, the inflammasome pathways activated during <jats:italic>L. monocytogenes<\/jats:italic> infection are only poorly defined. Here, we demonstrate that <jats:italic>L. monocytogenes<\/jats:italic> activates both the NLRP3 and the AIM2 inflammasome, with a predominant involvement of the AIM2 inflammasome. In addition, <jats:italic>L. monocytogenes<\/jats:italic>\u2010triggered cell death was diminished in the absence of both AIM2 and NLRP3, and is concomitant with increased intracellular replication of <jats:italic>L. monocytogenes<\/jats:italic>. Altogether, these data establish a role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria.<\/jats:p>","DOI":"10.1002\/eji.201040425","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T13:56:42Z","timestamp":1269352602000},"page":"1545-1551","source":"Crossref","is-referenced-by-count":233,"title":["<i>Listeria monocytogenes<\/i> is sensed by the NLRP3 and AIM2 inflammasome"],"prefix":"10.1002","volume":"40","author":[{"given":"Sarah","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Bauernfeind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ablasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunther","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eicke","family":"Latz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Hornung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132715"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.12.003"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0306164"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.12.004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132612"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2070"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40599"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156995"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1636"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04515"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900173"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1831"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.584-640.2001"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.12.012"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104911"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202476699"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.484"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.514"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7416"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2131-2139.2004"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.11.7558"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh041"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901346"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610762200"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2004.00360.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1724"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.12.003"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00184.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1128\/iai.65.10.4075-4081.1997","article-title":"The mechanism of cell death in Listeria monocytogenes\u2010infected murine macrophages is distinct from apoptosis","volume":"65","author":"Barsig J.","year":"1997","journal-title":"Infect. 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