{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:32:07Z","timestamp":1789990327034,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T00:00:00Z","timestamp":1280102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>OX40 stimulation is known to enhance activation of effector T cells and to inhibit induction and suppressive function of Treg. Here we uncovered a novel role of OX40 in sustaining Treg competitive fitness <jats:italic>in vivo<\/jats:italic>, during repopulation of lymphopenic hosts and reconstitution of BM chimeras. Defective expansion of OX40\u2010null Treg diminished their ability to suppress inflammation in a model of lymphopenia\u2010driven colitis. OX40\u2010mediated promotion of Treg fitness spanned beyond lymphopenic environments, as endogenous Treg in OX40\u2010null mice showed decreased accumulation during thymic development, enhanced susceptibility to antibody\u2010mediated depletion and defective turnover following thymectomy. <jats:italic>In vitro<\/jats:italic>, OX40\u2010deficient Treg were found to be intrinsically hyporesponsive to IL\u20102, in terms of Stat5 phosphorylation and proliferation, according to elevated SOCS1 content and reduced miR155 expression. Therefore, OX40 is a key factor in shaping Treg sensitivity to IL\u20102 and promoting their proliferation and survival, toward accurate immune regulation.<\/jats:p>","DOI":"10.1002\/eji.201040505","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T17:29:14Z","timestamp":1280165354000},"page":"2902-2913","source":"Crossref","is-referenced-by-count":56,"title":["A non\u2010redundant role for OX40 in the competitive fitness of Treg in response to IL\u20102"],"prefix":"10.1002","volume":"40","author":[{"given":"Silvia","family":"Piconese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Pittoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Burocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gorzanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Car\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tripodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario P.","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.04.010"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3580"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2959"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1371"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00191-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535637"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/90942"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1427"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1182\/blood-2007-01-070748","article-title":"OX40 costimulation turns off Foxp3+Tregs","volume":"110","author":"Vu M. 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