{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T07:41:56Z","timestamp":1697528516537},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T00:00:00Z","timestamp":1289433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have investigated whether rat Ly49 receptors can monitor <jats:italic>Listeria<\/jats:italic>\u2010infected intestinal epithelial cells through altered expression of MHC class I molecules. The rat colon carcinoma epithelial cell line CC531 infected with <jats:italic>Listeria<\/jats:italic> expressed higher levels of both classical and nonclassical MHC\u2010I molecules. Reporter cells expressing the activating Ly49s5 receptor displayed increased stimulatory responses when incubated with <jats:italic>Listeria<\/jats:italic>\u2010infected CC531 cells <jats:italic>in vitro<\/jats:italic>, which could be blocked with mAb 8G10 specific for nonclassical MHC\u2010I molecules of the <jats:italic>RT1<jats:sup>u<\/jats:sup><\/jats:italic> haplotype, but not with mAb OX18 reacting with classical MHC\u2010I molecules in this haplotype. Similar responses were observed against IFN\u2010\u03b3\u2010treated cells that also upregulated their expression of MHC\u2010I molecules. Thus, the Ly49s5 receptor can respond to increased levels of nonclassical MHC\u2010I molecules induced on target cells by either bacterial infection or cytokine stimulation. We furthermore found that splenic NK and NKT cells produced IFN\u2010\u03b3 in response to <jats:italic>Listeria<\/jats:italic>\u2010infected CC531 cells, and that this was not limited to Ly49\u2010expressing cells, since similar levels of IFN\u2010\u03b3 production were observed in Ly49<jats:sup>+<\/jats:sup> and Ly49<jats:sup>\u2212<\/jats:sup> NK cell subsets. Therefore, NK cells may recognize <jats:italic>Listeria<\/jats:italic>\u2010infected cells through both MHC\u2010I\u2010dependent and \u2010independent innate immune receptor systems.<\/jats:p>","DOI":"10.1002\/eji.201040651","type":"journal-article","created":{"date-parts":[[2010,9,30]],"date-time":"2010-09-30T08:15:07Z","timestamp":1285834507000},"page":"3535-3543","source":"Crossref","is-referenced-by-count":5,"title":["The activating rat Ly49s5 receptor responds to increased levels of MHC class Ib molecules on <i>Listeria monocytogenes<\/i>\u2010infected enteric epithelial cells"],"prefix":"10.1002","volume":"40","author":[{"given":"Hamid","family":"Shegarfi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke\u2010Zheng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit","family":"Inngjerdingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Vaage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bent","family":"Rolstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Naper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1461"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.5.2154-2161.1993"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2009.01.003"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.042308.113331"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115526"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.99"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017407.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90163-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.4049\/jimmunol.158.11.5297","article-title":"Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes\u2010infected IFN\u2010 gamma receptor\u2010deficient mice","volume":"158","author":"Dai W. 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