{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:14:12Z","timestamp":1791080052282,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T00:00:00Z","timestamp":1300665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Repeated infections and experimental prime\u2010boost regimens frequently result in the generation of secondary (2\u00b0) CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses. In contrast to primary (1\u00b0) CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, the parameters that influence the abundance and phenotype of 2\u00b0 effector and memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell populations are largely unknown. Here, we analyze the impact of different booster infections, Ag curtailment, and systemic inflammation on the quality and quantity of secondary CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses. We show that similar to 1\u00b0 CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses, the phenotype of 2\u00b0 effector and memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell populations is critically dependent on the nature of the infectious pathogen and the inflammatory milieu early after infection. In addition, systemic inflammation increases the number of 2\u00b0 effector and memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells after booster infections and immunizations. Therefore, our data reveal new means to boost the number of 2\u00b0 effector and memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in prime\u2010boost regimens and show a surprisingly high degree of plasticity in 2\u00b0 memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell phenotype that is controlled by systemic inflammation.\n                  <\/jats:p>","DOI":"10.1002\/eji.201040730","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T06:22:25Z","timestamp":1298010145000},"page":"1321-1333","source":"Crossref","is-referenced-by-count":32,"title":["Secondary CD8\n                    <sup>+<\/sup>\n                    T\u2010cell responses are controlled by systemic inflammation"],"prefix":"10.1002","volume":"41","author":[{"given":"Thomas C.","family":"Wirth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Starbeck\u2010Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Harty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir P.","family":"Badovinac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.54"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2251"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri778"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni804"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80469-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.04.010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00393.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070322"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni889"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.08.007"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00382.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.53"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1257"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.010"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050821"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901203"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.6842"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1396.043"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323730"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.11.009"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.014"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.005"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900319"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.07.001"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.12.018"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1098"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.10.4933"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.3760"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052237"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.2.831"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.01.088"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.9.4838"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-199588"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805452105"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4465"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5495.1354"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808997105"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00384.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081829"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1505"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.007"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040310"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902874"}],"container-title":["European 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