{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:13:24Z","timestamp":1697530404822},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T00:00:00Z","timestamp":1293580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Introgression of a New Zealand Black (NZB) chromosome 13 interval onto a C57BL\/6 (B6) background (B6.NZBc13) is sufficient to produce many hallmarks of lupus, including high\u2010titre anti\u2010chromatin antibody production, abnormal B\u2010 and T\u2010cell activation, and renal disease. In this study we sought to characterize the immune defects leading to these abnormalities. By generating hematopoietic chimeras and BCR transgenic mice, we show that the congenic autoimmune phenotype can be transferred by BM cells and requires the presence of autoreactive B cells. Using the hen egg white lysozyme immunoglobulin transgenic mouse model, we demonstrate that B\u2010cell anergy, deletion, and receptor editing are intact. Nevertheless, congenic B cells exhibit altered peripheral B\u2010cell selection, as demonstrated by enhanced survival and activation of endogenous B cells with autoreactivity to chromatin and Sm\/ribonucleoprotein. Given the autoantibody specificities to nuclear antigens, TLR signalling was assessed. B6.NZBc13 B cells were hyper\u2010responsive to poly(I:C), a TLR3 ligand, demonstrating enhanced proliferation and survival as compared to B6 B cells. Our findings indicate the presence of an intrinsic B\u2010cell defect on NZB chromosome 13 that results in hyper\u2010responsiveness to a dsRNA analogue and implicates its potential supporting role in the generation of autoimmunity in B6.NZBc13 mice.<\/jats:p>","DOI":"10.1002\/eji.201040983","type":"journal-article","created":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T07:57:44Z","timestamp":1291622264000},"page":"527-536","source":"Crossref","is-referenced-by-count":7,"title":["An intrinsic B\u2010cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice"],"prefix":"10.1002","volume":"41","author":[{"given":"Christina","family":"Loh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Pau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan\u2010Hua","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan E.","family":"Wither","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60342-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4049\/jimmunol.145.1.94","article-title":"The BM12 mutation and autoantibodies to dsDNA in NZB.H\u20102bm12 mice","volume":"145","author":"Chiang B. L.","year":"1990","journal-title":"J. Immunol."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.10.005"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200002)30:2<356::AID-IMMU356>3.0.CO;2-H"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4309"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6573"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1957"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.08.005"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8154"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.10.1639"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/334676a0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/374546a0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091982"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200635850"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3469"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091181"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636483"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20428"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124978"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.09.009"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/416603a"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050630"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.6491"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.24"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812922106"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.46"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900263"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2846"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20623"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.2.345"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.003"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.3.1451"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901163"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1553"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201040983","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201040983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:56:54Z","timestamp":1697461014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201040983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,29]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/eji.201040983"],"URL":"https:\/\/doi.org\/10.1002\/eji.201040983","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,29]]}}}