{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:34:35Z","timestamp":1791056075841,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T00:00:00Z","timestamp":1306281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Invariant natural killer T (iNKT) cells are involved in the intrahepatic immune response and in hepatitis. In particular, iNKT lymphocytes are responsible for hepatocyte death in concanavalin A\u2010induced hepatitis in mice. We examined the role of iNKT cells in acute hepatitis induced by a hepatotoxic agent, carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). WT and iNKT cell\u2010deficient (J\u03b118<jats:sup>\u2212\/\u2212<\/jats:sup>) mice were challenged with a single dose of 2.4\u2009g\/kg CCl<jats:sub>4<\/jats:sub> and both hepatic physiopathology and immune responses were studied. Plasma alanine and aspartate amino\u2010transferase levels were significantly higher in J\u03b118<jats:sup>\u2212\/\u2212<\/jats:sup> mice than in WT mice two days after CCl<jats:sub>4<\/jats:sub> administration. Chemokine CXCL1\/keratinocyte\u2010derived chemokine (KC) and MMP\u20108 were significantly higher in iNKT cell\u2010deficient mice than in control mice. The more severe liver injury in J\u03b118<jats:sup>\u2212\/\u2212<\/jats:sup> mice was associated with greater leukocyte infiltrate, which was enriched in neutrophils (CD11b<jats:sup>+<\/jats:sup>CD11c<jats:sup>\u2212<\/jats:sup>Gr\u20101<jats:sup>+<\/jats:sup> cells), in agreement with CXCL1\/KC and MMP\u20108 levels. Complementary experiments with NK\u2010depleted animals indicate a minor role for NK cells in the liver damage found in iNKT\u2010deficient mice. Thus, unlike for ConA\u2010induced hepatitis, we report that iNKT cells protect the liver against acute hepatitis induced by CCl<jats:sub>4<\/jats:sub> and limit neutrophil infiltration.<\/jats:p>","DOI":"10.1002\/eji.201041006","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T09:57:18Z","timestamp":1300183038000},"page":"1720-1732","source":"Crossref","is-referenced-by-count":26,"title":["Invariant natural killer T\u2010cell\u2010deficient mice display increased CCl<sub>4<\/sub>\u2010induced hepatitis associated with CXCL1 over\u2010expression and neutrophil infiltration"],"prefix":"10.1002","volume":"41","author":[{"given":"Mariette","family":"Lisbonne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"L'Helgoualc'h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendoline","family":"Nauwelaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Turlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Herbelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Piquet\u2010Pellorce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(02)00326-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-003-0008-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02074.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.5.741"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141711"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5343.1626"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200207)32:7<1897::AID-IMMU1897>3.0.CO;2-Y"},{"key":"e_1_2_6_9_2","first-page":"4","article-title":"Invariant Valpha14 NKT lymphocytes: a double\u2010edged immuno\u2010regulatory T cell population","volume":"14","author":"Lisbonne M.","year":"2003","journal-title":"Eur. 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