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Three signals \u2013 antigen, costimulation and inflammation \u2013 orchestrate optimal CD8<jats:sup>+<\/jats:sup> T\u2010cell priming and differentiation into effector and memory cells and shape T\u2010cell functional fate and ability to protect against challenge infections. While among the conventional spleen DCs (cDCs), the CD8\u03b1<jats:sup>+<\/jats:sup> but not the CD8\u03b1<jats:sup>\u2212<\/jats:sup> cDCs most efficiently mediate CD8<jats:sup>+<\/jats:sup> T\u2010cell priming, it is unclear which subset, irrespective of their capacity to process MHC class I\u2010associated antigens, is most efficient at inducing na\u00efve CD8<jats:sup>+<\/jats:sup> T\u2010cell differentiation into pathogen\u2010specific protective memory cells in vivo. Moreover, the origin of the required signals is still unclear. Using mice infected with the intracellular bacterium <jats:italic>Listeria monocytogenes<\/jats:italic>, we show that splenic CD8\u03b1<jats:sup>+<\/jats:sup> cDCs become endowed with all functional features to optimally prime protective memory CD8<jats:sup>+<\/jats:sup> T cells in vivo within only a few hours post\u2010immunization. Such programming requires both cytosolic signals resulting from bacterial invasion of the host cells and extracellular inflammatory mediators. Thus, these data designate these cells as the best candidates to facilitate the development of cell\u2010based vaccine therapy.<\/jats:p>","DOI":"10.1002\/eji.201041036","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T09:41:34Z","timestamp":1300268494000},"page":"1594-1605","source":"Crossref","is-referenced-by-count":27,"title":["Splenic CD8\u03b1<sup>+<\/sup> dendritic cells undergo rapid programming by cytosolic bacteria and inflammation to induce protective CD8<sup>+<\/sup> T\u2010cell memory"],"prefix":"10.1002","volume":"41","author":[{"given":"Laura","family":"Campisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saidi M'Homa","family":"Soudja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Cazareth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Bassand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lazzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Brau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Narni\u2010Mancinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Glaichenhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Geissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Lauvau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2251"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri746"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.10.012"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00365-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1845"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01088-06"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.4.2641"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526024"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136080"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087576"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.196"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164206"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34584"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02868.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03425.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00883.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070204"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064571"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb00999.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.4049\/jimmunol.138.7.2266","article-title":"Intracellular growth of Listeria monocytogenes as a prerequisite for in vivo induction of T cell\u2010mediated immunity","volume":"138","author":"Berche P.","year":"1987","journal-title":"J. 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