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In vitro evaluation shows that MDSC from multiple tissue sites have suppressive activity, and in vivo inhibition of MDSC enhances T\u2010cell function; however, the relative capacity of MDSC present at localized inflammatory sites or in peripheral tissues to suppress T\u2010cell responses in vivo has not been directly evaluated. In the current study, we observed that during a tissue\u2010specific inflammatory response, MDSC inhibition of CD8<jats:sup>+<\/jats:sup> T\u2010cell proliferation and IFN\u2010\u03b3 production was restricted to the inflammatory site. Using a prostate\u2010specific inflammatory model and a heterotopic prostate tumor model, we showed that MDSC from inflammatory sites or from tumor tissue possess immediate capacity to inhibit T\u2010cell function, whereas those isolated from peripheral tissues (spleens and liver) were not suppressive without activation of iNOS by exposure to IFN\u2010\u03b3. These data suggest that MDSC are important regulators of immune responses in the prostate during acute inflammation and the chronic inflammatory setting of tumor growth, and that regulation of T\u2010cell function by MDSC during a localized inflammatory response is restricted in vivo to the site of an ongoing immune response.<\/jats:p>","DOI":"10.1002\/eji.201041069","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T11:08:48Z","timestamp":1294139328000},"page":"749-759","source":"Crossref","is-referenced-by-count":114,"title":["In vivo suppressive function of myeloid\u2010derived suppressor cells is limited to the inflammatory site"],"prefix":"10.1002","volume":"41","author":[{"given":"Jessica M.","family":"Haverkamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Crist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett 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