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IL4I1 is also detected by immunohistochemistry in neoplastic cells from several B\u2010cell lymphomas and some non\u2010lymphoid tumors. To evaluate IL4I1's effect on tumor growth, we developed a mouse melanoma model constitutively coexpressing IL4I1 and the GP33 epitope. After GP33 vaccination, tumors developed more frequently in mice injected with IL4I1\u2010expressing cells in comparison with mice receiving control cells. Tumor escape was preceded by a rapid diminution of IFN\u2010\u03b3\u2010producing cytotoxic antitumor CD8<jats:sup>+<\/jats:sup> T cells. Moreover, tumor incidence was already increased when only 20% of the injected cells expressed IL4I1. The minimal IL4I1 activities leading to tumor escape were close to those detected in human melanoma and mesothelioma. Thus, we demonstrate the immunosuppressive functions of IL4I1 in vivo and suggest that IL4I1 facilitates human tumor growth by inhibiting the CD8<jats:sup>+<\/jats:sup> antitumor T\u2010cell response.<\/jats:p>","DOI":"10.1002\/eji.201041119","type":"journal-article","created":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T07:12:18Z","timestamp":1300691538000},"page":"1629-1638","source":"Crossref","is-referenced-by-count":77,"title":["IL4I1: an inhibitor of the CD8<sup>+<\/sup> antitumor T\u2010cell response in vivo"],"prefix":"10.1002","volume":"41","author":[{"given":"Fanette","family":"Lasoudris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Cousin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Prevost\u2010Blondel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Martin\u2010Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issam","family":"Abd\u2010Alsamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Ortonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Farcet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Molinier\u2010Frenkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00602.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25429"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040895"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31178"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00291.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-869-0_24"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00915.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0631-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24984"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm934"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.9.1363"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1232"},{"key":"e_1_2_6_16_2","first-page":"958s","article-title":"L\u2010Arginine regulates the expression of the T\u2010cell receptor zeta chain (CD3zeta) in Jurkat cells","volume":"7","author":"Taheri F.","year":"2001","journal-title":"Clin. 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