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By producing TNF and NO, CD11b<jats:sup>+<\/jats:sup> myeloid cells with a classical activation status (M1) contribute to parasitemia control in experimental <jats:italic>Trypanosoma congolense<\/jats:italic> infection in resistant C57BL\/6 mice. However, in these mice, IL\u201010 is required to regulate M1\u2010associated inflammation, avoiding tissue\/liver damage and ensuring prolonged survival. In an effort to dissect the mechanisms behind the anti\u2010inflammatory activity of IL\u201010 in <jats:italic>T. congolense<\/jats:italic>\u2010infected C57BL\/6 mice, we show, using an antibody blocking the IL\u201010 receptor, that IL\u201010 impairs the accumulation and M1 activation of TNF\/iNOS\u2010producing CD11b<jats:sup>+<\/jats:sup>Ly6C<jats:sup>+<\/jats:sup> cells in the liver. Using infected IL\u201010<jats:sup>flox\/flox<\/jats:sup>LysM\u2010Cre<jats:sup>+\/+<\/jats:sup> mice, we show that myeloid cell\u2010derived IL\u201010 limits M1 activation of CD11b<jats:sup>+<\/jats:sup>Ly6C<jats:sup>+<\/jats:sup> cells specifically at the level of TNF production. Moreover, higher production of TNF in infected IL\u201010<jats:sup>flox\/flox<\/jats:sup>LysM\u2010Cre<jats:sup>+\/+<\/jats:sup> mice is associated with reduced nuclear accumulation of the NF\u2010\u03baB p50 subunit in CD11b<jats:sup>+<\/jats:sup> M1 cells. Furthermore, in infected p50<jats:sup>\u2212\/\u2212<\/jats:sup> mice, TNF production by CD11b<jats:sup>+<\/jats:sup>Ly6C<jats:sup>+<\/jats:sup> cells and liver injury increases. These data suggest that preferential nuclear accumulation of p50 represents an IL\u201010\u2010dependent anti\u2010inflammatory mechanism in M1\u2010type CD11b<jats:sup>+<\/jats:sup> myeloid cells that regulates the production of pathogenic TNF during <jats:italic>T. congolense<\/jats:italic> infection in resistant C57BL\/6 mice.<\/jats:p>","DOI":"10.1002\/eji.201041307","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T07:11:47Z","timestamp":1312182707000},"page":"3270-3280","source":"Crossref","is-referenced-by-count":24,"title":["IL\u201010 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF\u2010\u03baB p50 member in <i>Trypanosoma congolense<\/i> infection\u2010resistant C57BL\/6 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