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After challenge with a contact allergen, we observed augmented hypersensitivity reactions with increased numbers of activated T lymphocytes in the skin of PPAR\u2010\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Furthermore, following antigen challenge, the percentages of Tregs in the blood, draining lymph nodes and skin were decreased in these mice. PPAR\u2010\u03b1 deficiency impaired the production of IL\u20102 in lymph nodes, whereas TGF\u2010\u03b2 levels remained unchanged. Injection of IL\u20102 into PPAR\u2010\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> mice restored the Treg population in the skin\u2010draining lymph nodes of allergen\u2010challenged mice. In vivo induction of Tregs from WT CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup> T cells was impaired when adoptively transferred into PPAR\u2010\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> mice as compared with transfer into WT mice, and reversed by injection of IL\u20102 into PPAR\u2010\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Furthermore, the suppressive capacity of PPAR\u2010\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> Tregs was impaired when compared to WT Tregs in vitro and in co\u2010adoptive transfer experiments. Finally, injection of IL\u20102 to PPAR\u2010\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> mice decreased skin inflammation to a level similar to WT mice. In conclusion, the pro\u2010inflammatory skin phenotype of PPAR\u2010\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup> mice is due to lack of IL\u20102\u2010mediated Treg induction in these mice.<\/jats:p>","DOI":"10.1002\/eji.201041357","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T16:19:26Z","timestamp":1303316366000},"page":"1980-1991","source":"Crossref","is-referenced-by-count":22,"title":["Lack of IL\u20102 in PPAR\u2010\u03b1\u2010deficient mice triggers allergic contact dermatitis by affecting regulatory T cells"],"prefix":"10.1002","volume":"41","author":[{"given":"Sandrine","family":"Dubrac","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Elentner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Schoonjans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Auwerx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schmuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90200-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0088"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.036"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.085118"},{"key":"e_1_2_6_6_2","first-page":"44","article-title":"Combinatorial roles of nuclear receptors in inflammation and immunity","volume":"6","author":"Glass C. 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