{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:09:17Z","timestamp":1791173357610,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Specific NK cell killer inhibitory receptor (KIR):HLA haplotype combinations have been associated with successful clearance of acute and chronic HCV infection. Whether an imbalance of activating NK cell receptors also contributes to the outcome of treatment of chronic HCV infection, however, is not known. We studied peripheral NK cell phenotype and function in 28 chronically viraemic HCV genotype I treatment\u2010na\u00efve patients who underwent treatment with pegylated IFN\u2010\u03b1 and ribavirin. At baseline, chronically infected patients with sustained virological response (SVR) had reduced CD56\n                    <jats:sup>bright<\/jats:sup>\n                    CD16\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    cell populations, increased CD56\n                    <jats:sup>dull<\/jats:sup>\n                    CD16\n                    <jats:sup>+<\/jats:sup>\n                    NK cell proportions, and lower expression of NKp30, DNAM\u20101, and CD85j. Similarly, reduced NK cell IFN\u2010\u03b3 production but increased degranulation was observed among nonresponding (NR) patients. After treatment, CD56\n                    <jats:sup>bright<\/jats:sup>\n                    CD16\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    NK cell numbers increased in both SVR and NR patients, with a parallel significant increase in activating NKp30 molecule densities in SVR patients only. In vitro experiments using purified NK cells in the presence of rIL\u20102 and IFN\u2010\u03b1 confirmed upregulation of NKp30 and also of NKp46 and DNAM\u20101 in patients with subsequent SVR. Thus, differences in patient NK cell receptor expression and modulation during chronic HCV\u20101 infection are associated with subsequent outcome of standard treatment. Individual activating receptor expression\/function integrates with KIR:HLA genotype carriage to determine the clearance of HCV infection upon treatment.\n                  <\/jats:p>","DOI":"10.1002\/eji.201041361","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T05:27:24Z","timestamp":1308720444000},"page":"2905-2914","source":"Crossref","is-referenced-by-count":71,"title":["Activating NK cell receptor expression\/function (NKp30, NKp46, DNAM\u20101) during chronic viraemic HCV infection is associated with the outcome of combined treatment"],"prefix":"10.1002","volume":"41","author":[{"given":"Federica","family":"Bozzano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Picciotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Marras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Fazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Olive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Moretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"De Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840360704"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097670"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.9.1499"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80044-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.1395"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1066"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0304197"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6480"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324141"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425251"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-2058"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3682"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp046"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.10.6072"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200635989"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.076463"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22624"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.006"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.4049\/jimmunol.163.4.2314","article-title":"The human liver contains multiple populations of NK cells, T cells and CD3+CD56+natural T cells with distinct cytotoxic activities and Th1, Th2 and Th0 cytokine secretion patterns","volume":"163","author":"Doherty D. 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