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Here, we show that efficient Th1 priming after <jats:italic>Salmonella<\/jats:italic> infection requires CD11c<jats:sup>+<\/jats:sup>CD11b<jats:sup>hi<\/jats:sup>F4\/80<jats:sup>+<\/jats:sup> monocyte\u2010derived dendritic cells (moDCs). In non\u2010infected spleens, moDCs are absent from T\u2010cell zones (T zones) of secondary lymphoid tissues, but by 24\u2009h post\u2010infection moDCs are readily discernible in these sites. The accumulation of moDCs is more dependent upon bacterial viability than bacterial virulence. Kinetic studies showed that moDCs were necessary to prime but not sustain Th1 responses, while ex vivo studies showed that antigen\u2010experienced moDCs were sufficient to induce T\u2010cell proliferation and IFN\u2010\u03b3 production via a TNF\u2010\u03b1\u2010dependent mechanism. Importantly, moDCs and cDCs when co\u2010cultured induced superior Th1 differentiation than either subset alone, and this activity was independent of TNF\u2010\u03b1. Thus, optimal Th1 development to <jats:italic>Salmonella<\/jats:italic> requires the rapid accumulation of moDCs within T zones and their collaboration with cDCs.<\/jats:p>","DOI":"10.1002\/eji.201141440","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T08:31:03Z","timestamp":1306917063000},"page":"2654-2665","source":"Crossref","is-referenced-by-count":38,"title":["T\u2010zone localized monocyte\u2010derived dendritic cells promote Th1 priming to <i>Salmonella<\/i>"],"prefix":"10.1002","volume":"41","author":[{"given":"Adriana","family":"Flores\u2010Langarica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeeda","family":"Bobat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Hitchcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E.","family":"Coughlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Van Rooijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C.M.","family":"MacLennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam F.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00592.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00289-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.8.1193"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.4049\/jimmunol.156.9.3321","article-title":"Salmonella typhimurium aroA\u2010 infection in gene\u2010targeted immunodeficient mice: major role of CD4+TCR\u2010alpha beta cells and IFN\u2010gamma in bacterial clearance independent of intracellular location","volume":"156","author":"Hess J.","year":"1996","journal-title":"J. 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