{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:28:54Z","timestamp":1791412134926,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T00:00:00Z","timestamp":1312416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Resident CD8\n                    <jats:sup>+<\/jats:sup>\n                    DCs perform several functions, including cross\u2010presenting antigen and rapidly engulfing the Gram\u2010positive intracellular pathogen\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    . Little is known about how these functions of CD8\n                    <jats:sup>+<\/jats:sup>\n                    DCs are modulated. Here, we show that granulocyte\u2010macrophage CSF (GM\u2010CSF), a cytokine that exists at low levels at steady state but is elevated during infection and inflammation, enhances cross\u2010presentation and rapid uptake of\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    by resident CD8\n                    <jats:sup>+<\/jats:sup>\n                    DCs. This previously unrecognized functional enhancement of CD8\n                    <jats:sup>+<\/jats:sup>\n                    DCs by GM\u2010CSF was independent of promoting DC survival in vitro. Enhancement of these functions by GM\u2010CSF was also marked by CD103 expression on CD8\n                    <jats:sup>+<\/jats:sup>\n                    DCs that was strongly regulated by GM\u2010CSF. Our findings not only identify GM\u2010CSF as a key molecule regulating CD8\n                    <jats:sup>+<\/jats:sup>\n                    DC function, but also as a factor responsible for functional heterogeneity of CD8\n                    <jats:sup>+<\/jats:sup>\n                    DCs that is at least substantially demarcated by CD103 expression.\n                  <\/jats:p>","DOI":"10.1002\/eji.201141540","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T05:57:19Z","timestamp":1307685439000},"page":"2585-2595","source":"Crossref","is-referenced-by-count":103,"title":["GM\u2010CSF increases cross\u2010presentation and CD103 expression by mouse CD8\n                    <sup>+<\/sup>\n                    spleen dendritic cells"],"prefix":"10.1002","volume":"41","author":[{"given":"Yifan","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma 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A.","family":"Villadangos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P.","family":"Wicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)\u2010deficient mice","volume":"162","author":"Schon M. 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