{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:48Z","timestamp":1790617248291,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:00:00Z","timestamp":1324339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The generation of effective type 1 T helper (Th1)\u2010cell responses is required for immunity against intracellular bacteria. However, some intracellular bacteria require interleukin (IL)\u201017 to drive Th1\u2010cell immunity and subsequent protective host immunity. Here, in a model of <jats:italic>Mycobacterium bovis<\/jats:italic> Bacille Calmette\u2013Guerin (BCG) vaccination in mice, we demonstrate that the dependence on IL\u201017 to drive Th1\u2010cell responses is a host mechanism to overcome bacteria\u2010induced IL\u201010 inhibitory effects. We show that BCG\u2010induced prostaglandin\u2010E2 (PGE2) promotes the production of IL\u201010 which limits Th1\u2010cell responses, while simultaneously inducing IL\u201023 and Th17\u2010cell differentiation. The ability of IL\u201017 to downregulate IL\u201010 and induce IL\u201012 production allows the generation of subsequent Th1\u2010cell responses. Accordingly, BCG\u2010induced Th17\u2010cell responses precede the generation of Th1\u2010cell responses in vivo, whereas the absence of the IL\u201023 pathway decreases BCG vaccine\u2010induced Th17 and Th1\u2010cell immunity and subsequent vaccine\u2010induced protection upon <jats:italic>M. tuberculosis<\/jats:italic> challenge. Importantly, in the absence of IL\u201010, BCG\u2010induced Th1\u2010cell responses occur in an IL\u201017\u2010independent manner. These novel data demonstrate a role for the IL\u201023\/IL\u201017 pathway in driving Th1\u2010cell responses, specifically to overcome IL\u201010\u2010mediated inhibition and, furthermore, show that in the absence of IL\u201010, the generation of BCG\u2010induced Th1\u2010cell immunity is IL\u201017 independent.<\/jats:p>","DOI":"10.1002\/eji.201141569","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T10:13:10Z","timestamp":1321870390000},"page":"364-373","source":"Crossref","is-referenced-by-count":162,"title":["IL\u201023\u2010dependent IL\u201017 drives Th1\u2010cell responses following <i>Mycobacterium bovis<\/i> BCG vaccination"],"prefix":"10.1002","volume":"42","author":[{"given":"Radha","family":"Gopal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nata\u0161a","family":"Obermajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Slight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Nuthalapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushtaq","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Kalinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabaana A.","family":"Khader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063814"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00439-002-0873-5","article-title":"Influence of interleukin\u201012 receptor beta1 polymorphisms on tuberculosis","volume":"112","author":"Akahoshi M.","year":"2003","journal-title":"Hum. 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