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The role of chemokines and their receptors in viral infections including HIV\u20101 was predicted from the early studies of HIV\u20101 co\u2010receptor CCR5 and its ligands and a divergent role of C\u2010C chemokines in HIV\u20101 pathogenesis has been established. For example, CCL3 (MIP\u20101\u03b1), CCL4 (MIP\u20101\u03b2) and CCL5 (RANTES) have been shown to possess antiviral effects by binding to the HIV\u20101 co\u2010receptor CCR5, whereas CCL2, a pro\u2010inflammatory chemokine, supports HIV\u20101 replication despite being a member of same chemokine family. Furthermore, the well\u2010established role of CCL2 in driving the Th2 immune response supports its potential role in HIV\u20101\/AIDS. Recent reports suggest multiple pathways of CCL2 affect HIV\u20101 infection. In this review, we provide a comprehensive overview of the role and potential mechanisms of the HIV\u20101\u2010CCL2 interplay in driving virus\u2010induced immuno\u2010pathology, suggesting that CCL2 could be an anti\u2010inflammatory target in the treatment of HIV\u20101 infection.<\/jats:p>","DOI":"10.1002\/eji.201141676","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T12:34:10Z","timestamp":1320928450000},"page":"3412-3418","source":"Crossref","is-referenced-by-count":49,"title":["CCL2: A potential prognostic marker and target of anti\u2010inflammatory strategy in HIV\/AIDS pathogenesis"],"prefix":"10.1002","volume":"41","author":[{"given":"Abdul 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