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Here, we demonstrate that IL<\/jats:styled-content>\u201010 deficiency renders LPS<\/jats:styled-content> treatment ineffective in regulating the expression of CD<\/jats:styled-content>40, CD<\/jats:styled-content>80, CD<\/jats:styled-content>86, B<\/jats:styled-content>7\u2010H<\/jats:styled-content>2, and B<\/jats:styled-content>7\u2010DC<\/jats:styled-content> on dendritic cells (DC<\/jats:styled-content>s) and blocks upregulation of IL<\/jats:styled-content>\u201027. This inability to respond to LPS<\/jats:styled-content> was found in both IL<\/jats:styled-content>\u201010\u2212\/\u2212<\/jats:sup> bone marrow derived and splenic DC<\/jats:styled-content>s. Compared with wild\u2010type DC<\/jats:styled-content>s, IL<\/jats:styled-content>\u201010\u2212\/\u2013<\/jats:sup> DC<\/jats:styled-content>s expressed similar levels of TLR<\/jats:styled-content>4 and CD<\/jats:styled-content>14, but produced less LPS<\/jats:styled-content>\u2010binding protein. The deficiency in LPS<\/jats:styled-content>\u2010binding protein production may explain the failure of IL<\/jats:styled-content>\u201010\u2212\/\u2212<\/jats:sup> DC<\/jats:styled-content>s to respond normally to LPS<\/jats:styled-content>. Moreover, lack of IL<\/jats:styled-content>\u201010 modulated the proportions of CD<\/jats:styled-content>11c+<\/jats:sup>CD<\/jats:styled-content>8+<\/jats:sup> and CD<\/jats:styled-content>11c+<\/jats:sup>B<\/jats:styled-content>220+<\/jats:sup> DC<\/jats:styled-content>s, which play an important role in local inflammatory responses and tolerance. IL<\/jats:styled-content>\u201010 deficiency also blocked expression of galectin\u20101, CD<\/jats:styled-content>205, and CD<\/jats:styled-content>103, which are necessary for central and peripheral tolerance. While they did not respond to LPS<\/jats:styled-content>, IL<\/jats:styled-content>\u201010\u2212\/\u2212<\/jats:sup> DC<\/jats:styled-content>s produced increased levels of IL<\/jats:styled-content>\u20106 and CCL<\/jats:styled-content>4 after TNF<\/jats:styled-content>\u2010\u03b1 treatment. Together, our results demonstrate that IL<\/jats:styled-content>\u201010 deficiency affects the immune functions of DC<\/jats:styled-content>s, which may contribute to the increased severity of autoimmune diseases seen in IL<\/jats:styled-content>\u201010\u2212\/\u2212<\/jats:sup> mice.<\/jats:p>","DOI":"10.1002\/eji.201141733","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T15:24:40Z","timestamp":1337786680000},"page":"1449-1458","source":"Crossref","is-referenced-by-count":26,"title":["IL<\/scp>\u201010 deficiency blocks the ability of LPS<\/scp> to regulate expression of tolerance\u2010related molecules on dendritic cells"],"prefix":"10.1002","volume":"42","author":[{"given":"Fang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogoljub","family":"Ciric","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Cullimore","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Lauretti","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Gonnella","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Xian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdolmohamad","family":"Rostami","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06175"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.06.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1088-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00718.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-93864-4_5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0708420"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3556"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00242.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152809787582507"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.06.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1205751"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00706.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2004.05.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(02)00068-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1791"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1772"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.11.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1680"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.11.016"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.6923"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080414"},{"key":"e_1_2_7_24_1","first-page":"21","article-title":"Loss of CD103+ intestinal dendritic cells during colonic inflammation","volume":"16","author":"Strauch U. 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