{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:11:29Z","timestamp":1791058289276,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deficiency in the guanine nucleotide exchange factor dedicator of cytokinesis 8 (DOCK8) causes a human immunodeficiency syndrome associated with recurrent sinopulmonary and viral infections. We have recently identified a DOCK8\u2010deficient mouse strain, carrying an ethylnitrosourea\u2010induced splice\u2010site mutation that shows a failure to mature a humoral immune response due to the loss of germinal centre B cells. In this study, we turned to T\u2010cell immunity to investigate further the human immunodeficiency syndrome and its association with decreased peripheral CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells. Characterisation of the DOCK8\u2010deficient mouse revealed T\u2010cell lymphopenia, with increased T\u2010cell turnover and decreased survival. Egress of mature CD4<jats:sup>+<\/jats:sup> thymocytes was reduced with increased migration of these cells to the chemokine CXCL12. However, despite the two\u2010fold reduction in peripheral na\u00efve T cells, the DOCK8\u2010deficient mice generated a normal primary CD8<jats:sup>+<\/jats:sup> immune response and were able to survive acute influenza virus infection. The limiting effect of DOCK8 was in the normal survival of CD8<jats:sup>+<\/jats:sup> memory T cells after infection. These findings help to explain why DOCK8\u2010deficient patients are susceptible to recurrent infections and provide new insights into how T\u2010cell memory is sustained.<\/jats:p>","DOI":"10.1002\/eji.201141759","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T10:23:38Z","timestamp":1317723818000},"page":"3423-3435","source":"Crossref","is-referenced-by-count":115,"title":["DOCK8 is essential for T\u2010cell survival and the maintenance of CD8<b><sup>+<\/sup><\/b> T\u2010cell memory"],"prefix":"10.1002","volume":"41","author":[{"given":"Teresa","family":"Lambe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy L.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya L.","family":"Crockford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphaine","family":"Bouriez\u2010Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling M.","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung H. 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