{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:35:14Z","timestamp":1791398114496,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of a successful vaccine against HIV is likely to require the induction of strong and long\u2010lasting humoral immune responses at the mucosal portal of virus entry. Hence, the design of a vaccine strategy able to induce mucosal antibodies and in particular specific IgA, may be crucial to providing immune protection. Nasal immunisation is known to induce specific IgG and IgA responses in the cervicovaginal mucosa; however, there is an urgent need for the development of safe, effective and accessible mucosal adjuvants for nasal application in humans. To reduce the potential for adverse events associated with some nasal adjuvants, we have assessed whether the B\u2010cell\u2010activating cytokines APRIL, BAFF and TSLP enhance humoral immune responses to HIV\u20101 gp140. Following intranasal immunisation, TSLP but not APRIL or BAFF induced strong humoral responses both in serum and mucosa. The adjuvant effect of TSLP on humoral responses was similar to that of cholera toxin (CT). The use of TSLP as an adjuvant skewed both the cellular and humoral immune responses towards Th2 cells. This is the first time that TSLP has been demonstrated to have a positive effect as a mucosal adjuvant, and specifically to promote mucosal and systemic responses to HIV gp140.<\/jats:p>","DOI":"10.1002\/eji.201141787","type":"journal-article","created":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T07:31:42Z","timestamp":1320651102000},"page":"353-363","source":"Crossref","is-referenced-by-count":47,"title":["Thymic stromal lymphopoietin (TSLP) acts as a potent mucosal adjuvant for HIV\u20101 gp140 vaccination in mice"],"prefix":"10.1002","volume":"42","author":[{"given":"Griet A.","family":"Van Roey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio A.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Tregoning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J.","family":"Shattock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.03.036"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.51.1.311"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1213"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1777"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/08830180802684331"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006999"},{"key":"e_1_2_6_8_2","first-page":"254","article-title":"Mutant TNF\u2010\u03b1, mTNF\u2010K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV","volume":"65","author":"Kayamuro H.","year":"2010","journal-title":"Pharmazie"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.11.083"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2007.0148"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6850"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00447-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.4049\/jimmunol.160.4.2000","article-title":"HIV\u20101 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with oligomeric gp160","volume":"160","author":"VanCott T. C.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.2.292"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901068"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/508748"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.6.960"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101317"},{"key":"e_1_2_6_19_2","first-page":"321","article-title":"A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells","volume":"22","author":"Friend S. L.","year":"1994","journal-title":"Exp. Hematol."},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4049\/jimmunol.162.2.677","article-title":"Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism","volume":"162","author":"Levin S. D.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2008.12"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni805"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1434"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni829"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03241.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.3931"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.134"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.110"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.4.2465"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.1.51"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.6.3578"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.5861"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3268"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.04.006"},{"key":"e_1_2_6_35_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4049\/jimmunol.182.Supp.36.15","article-title":"The regulation and function of the TSLP receptor in the airway epithelium","volume":"182","author":"Miazgowicz M.","year":"2009","journal-title":"J. Immunol."},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1740"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.3.1396"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6720"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041195"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1641"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00023-6"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2006.04.006"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.04.023"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.23.11367-11376.2000"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009381"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201141787","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201141787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:27:10Z","timestamp":1697462830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201141787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,19]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/eji.201141787"],"URL":"https:\/\/doi.org\/10.1002\/eji.201141787","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,19]]}}}