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Studies in mice infected with the helminth parasite <jats:italic>Schistosoma mansoni<\/jats:italic> have been particularly helpful in defining the in vivo function of classically and alternatively activated macrophages (AAM\u03d5s). These studies have shown that AAM\u03d5s protect mice from acute and chronic <jats:italic>S. mansoni<\/jats:italic> infection through distinct mechanisms, which are discussed in this <jats:italic>Viewpoint<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.201141869","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T13:09:17Z","timestamp":1318856957000},"page":"2509-2514","source":"Crossref","is-referenced-by-count":158,"title":["Macrophage activation governs schistosomiasis\u2010induced inflammation and fibrosis"],"prefix":"10.1002","volume":"41","author":[{"given":"Luke","family":"Barron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,26]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2741\/2692"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132532"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0710409"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1937"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002003"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255354"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/383787a0"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000899"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1671"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00291.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34261"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri843"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00176.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762002000700002"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00107-4"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4049\/jimmunol.163.1.337","volume":"163","author":"Jankovic D.","year":"1999","journal-title":"J. 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