{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:07:50Z","timestamp":1759410470260},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T00:00:00Z","timestamp":1326844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After infection or vaccination, antigen\u2010specific T cells proliferate then contract in numbers to a memory set point. T\u2010cell contraction is observed after both acute and prolonged infections although it is unknown if contraction is regulated similarly in both scenarios. Here, we show that contraction of antigen\u2010specific CD8<jats:sup>+<\/jats:sup> and CD4<jats:sup>+<\/jats:sup> T cells is markedly reduced in TNF\/perforin\u2010double deficient (DKO) mice responding to attenuated <jats:italic>Listeria monocytogenes<\/jats:italic> infection. Reduced contraction in DKO mice was associated with delayed clearance of infection and sustained T\u2010cell proliferation during the normal contraction interval. Mechanistically, sustained T\u2010cell proliferation mapped to prolonged infection in the absence of TNF; however, reduced contraction required the additional absence of perforin since T cells in mice lacking either TNF or perforin (singly deficient) underwent normal contraction. Thus, while T\u2010cell contraction after acute infection is independent of peforin, a perforin\u2010dependent pathway plays a previously unappreciated role to mediate contraction of antigen\u2010specific CD8<jats:sup>+<\/jats:sup> and CD4<jats:sup>+<\/jats:sup> T cells during prolonged <jats:italic>L. monocytogenes<\/jats:italic> infection.<\/jats:p>","DOI":"10.1002\/eji.201141902","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T10:14:09Z","timestamp":1323684849000},"page":"629-640","source":"Crossref","is-referenced-by-count":5,"title":["Perforin plays an unexpected role in regulating T\u2010cell contraction during prolonged <i>Listeria monocytogenes<\/i> infection"],"prefix":"10.1002","volume":"42","author":[{"given":"Nathan W.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaruni","family":"Khanolkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Hancox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan W.","family":"Heusel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Harty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2251"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.18.4728"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200635897"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00855-06"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808997105"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.12.017"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.12.014"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.010"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5495.1354"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1098"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00847-06"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.8.3906-3918.2004"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.202-213.2005"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0407240"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni804"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4911-4927.2003"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.9.5679"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.4254"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509054103"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.4.1397"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3402"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1877"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.275"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6833"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90169-4"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2000.00889.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052237"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.2.831"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.014"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1679"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(99)80059-X"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.1043"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.02.002"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb01010.x"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00333-3"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102104"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","unstructured":"Butler N. 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