{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:55:44Z","timestamp":1787500544173,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T00:00:00Z","timestamp":1324944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Definition of protective immunity induced by effective vaccines is important for the design of new pathogen control strategies. Inactivation of the PhoP response\u2010regulator in\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    results in a highly attenuated strain that demonstrates impressive protective efficacy in pre\u2010clinical models of tuberculosis. In this report we demonstrate that the protection afforded by the\n                    <jats:italic>M. tuberculosis phoP<\/jats:italic>\n                    mutant strain is associated with the long\u2010term maintenance of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell memory. Immunization of mice with SO2 resulted in enhanced expansion of\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    \u2010specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells compared with vaccination with the BCG vaccine, with an increased frequency of these cells persisting at extended time\u2010points after vaccination. Strikingly, vaccination with SO2 resulted in sustained generation of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells displaying a central memory phenotype, a property not shared by BCG. Further, SO2 vaccination markedly improved the generation of polyfunctional cytokine\u2010secreting CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells compared with BCG vaccination. The improved generation of functionally competent memory T cells by SO2 correlated with augmented recall responses in SO2\u2010vaccinated animals after challenge with virulent\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    . This study defines a mechanism for the protective effect of the SO2 vaccine and suggests that deletion of defined virulence networks may provide vaccine strains with potent immuno\u2010stimulatory properties.\n                  <\/jats:p>","DOI":"10.1002\/eji.201141903","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T06:44:35Z","timestamp":1321944275000},"page":"385-392","source":"Crossref","is-referenced-by-count":41,"title":["Protective immunity afforded by attenuated, PhoP\n                    <i>\u2010<\/i>\n                    deficient\n                    <i>Mycobacterium tuberculosis<\/i>\n                    is associated with sustained generation of CD4\n                    <sup>+<\/sup>\n                    T\u2010cell memory"],"prefix":"10.1002","volume":"42","author":[{"given":"Jonathan K.","family":"Nambiar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan I.","family":"Aguilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Takatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick J.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Triccas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,27]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"WHO GlobalTB control \u2013 epidemiology strategy financing. 2009. 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