{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:42:02Z","timestamp":1768412522563,"version":"3.49.0"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"IL<\/jats:styled-content>\u201017 is a signature cytokine of T<\/jats:styled-content>h17 cells implicated in the induction and progression of chronic inflammatory diseases. Several studies in C<\/jats:styled-content>57BL<\/jats:styled-content>\/6 mice, immunized with soluble schistosome egg Ags (SEA) in complete Freund's adjuvant (CFA), and subsequently infected with S<\/jats:styled-content>chistosoma mansoni<\/jats:italic> (S<\/jats:styled-content>. mansoni<\/jats:italic>) have shown that severe hepatic granulomatous inflammation is correlated with high levels of IL<\/jats:styled-content>\u201017. Here, using a S<\/jats:styled-content>chistosoma japonicum<\/jats:italic> (S. japonicum<\/jats:italic>) larvae infection model in C<\/jats:styled-content>57BL<\/jats:styled-content>\/6 mice, we analyzed the dynamic expression of IL<\/jats:styled-content>\u201017 in infected livers by RT<\/jats:styled-content>\u2010qPCR<\/jats:styled-content> and ELISA<\/jats:styled-content>. Our results showed that IL<\/jats:styled-content>\u201017 expression was elevated during the course of infection. The temporal expression of IL<\/jats:styled-content>\u201017 and cytokines\/chemokines involved in the induction and effector function of T<\/jats:styled-content>h17 cells was paralleled with hepatic granulomatous inflammation. Treatment of S<\/jats:italic>. japonicum<\/jats:italic> infected mice with IL<\/jats:styled-content>\u201017\u2010neutralizing mA<\/jats:styled-content>b resulted in significant downmodulation of granulomatous inflammation and hepatocyte necrosis. The protection was associated with lower expression of proinflammatory cytokines\/chemokines, such as IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u20101\u03b2, CXCL<\/jats:styled-content>1, and CXCL<\/jats:styled-content>2 and a reduced number of infiltrating neutrophils. Anti\u2010IL<\/jats:styled-content>\u201017 mA<\/jats:styled-content>b significantly ameliorated hepatic granulomatous inflammation, partly through the downregulation of proinflammatory cytokines\/chemokines and recruitment of neutrophils. Our data indicate a pathogenic role of T<\/jats:styled-content>h17\/IL<\/jats:styled-content>\u201017 in hepatic immunopathology in S<\/jats:styled-content>. japonicum<\/jats:italic> infected mice.<\/jats:p>","DOI":"10.1002\/eji.201141933","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T11:28:19Z","timestamp":1339154899000},"page":"1523-1535","source":"Crossref","is-referenced-by-count":72,"title":["IL<\/scp>\u201017 neutralization significantly ameliorates hepatic granulomatous inflammation and liver damage in S<\/scp>chistosoma japonicum<\/i> infected mice"],"prefix":"10.1002","volume":"42","author":[{"given":"Yuxia","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Immunology Anhui Medical University P.R. China"},{"name":"Department of Pathophysiology Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Anhui Medical University P.R. China"},{"name":"Anhui Provincial Laboratory of Microbiology & Parasitology Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenda","family":"Gao","sequence":"additional","affiliation":[{"name":"Antagen Institute for Biomedical Research Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Anhui Medical University P.R. China"},{"name":"Anhui Provincial Laboratory of Microbiology & Parasitology Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Anhui Medical University P.R. China"},{"name":"Anhui Provincial Laboratory of Microbiology & Parasitology Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gui","sequence":"additional","affiliation":[{"name":"Integrated laboratory of Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dake","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Anhui Medical University P.R. China"},{"name":"Integrated laboratory of Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Anhui Medical University P.R. China"},{"name":"Anhui Provincial Laboratory of Microbiology & Parasitology Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiping","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Anhui Medical University P.R. China"},{"name":"Anhui Provincial Laboratory of Microbiology & Parasitology Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology Anhui Medical University P.R. China"},{"name":"Department of Pathophysiology Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jijia","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Anhui Medical University P.R. China"},{"name":"Anhui Provincial Laboratory of Microbiology & Parasitology Anhui Medical University P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70521-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00176.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.07.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri843"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/262397a0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4049\/jimmunol.118.2.594","article-title":"Schistosomiasis in the congenitally athymic (nude) mouse. I. Thymic dependency of eosinophilia, granuloma formation, and host morbidity","volume":"118","author":"Phillips S. M.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/iai.54.3.820-826.1986","article-title":"Anti\u2010L3T4 antibody treatment suppresses hepatic granuloma formation and abrogates antigen\u2010induced interleukin\u20102 production in \n Schistosoma mansoni infection","volume":"54","author":"Mathew R. C.","year":"1986","journal-title":"Infect. Immun."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00002-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070663"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0502-500"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/135245859900500206"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2005.11.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070690"},{"key":"e_1_2_7_18_1","first-page":"419","article-title":"Proinflammatory cytokine interleukin\u201017 and its role in pathogenesis of rheumatoid arthritis","volume":"40","author":"Leonaviciene L.","year":"2004","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6173"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.3.1416"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7739"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100014"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3920"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1970.19.292"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4269\/ajtmh.1978.27.271","article-title":"The \n Schistosoma japonicum egg granuloma. II. Cellular composition, granuloma size, and immunologic concomitants","volume":"27","author":"Warren K. S.","year":"1978","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231258498"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000900052"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.435"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1376"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh379"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060285"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1496"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2486"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8559"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901504"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.4049\/jimmunol.1101445","article-title":"The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL\u201023 and IL\u20101beta","volume":"187","author":"Shainheit M. G.","journal-title":"J. Immunol"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2593"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.117929"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1391"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5703"},{"key":"e_1_2_7_44_1","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1128\/iai.59.9.2934-2940.1991","article-title":"Dynamic analysis of splenic Th1 and Th2 lymphocyte functions in mice infected with \n Schistosoma japonicum","volume":"59","author":"Xu Y. H.","year":"1991","journal-title":"Infect. Immun."},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/eji.201041327","article-title":"Exacerbated egg\u2010induced immunopathology in murine \n Schistosoma mansoni infection is primarily mediated by IL\u201017 and restrained by IFN\u2010gamma","volume":"41","author":"Rutitzky L. I.","journal-title":"Eur. J. Immunol"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939325"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002272"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001399"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4662"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4466"},{"key":"e_1_2_7_51_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri2800","article-title":"Innate IL\u201017\u2010producing cells: the sentinels of the immune system","volume":"10","author":"Cua D. J.","journal-title":"Nat. Rev. Immunol"},{"key":"e_1_2_7_52_1","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.4049\/jimmunol.1002283","article-title":"Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN\u2010gamma\u2010 or IL\u201017\u2010producing gammadelta T cells upon infection","volume":"185","author":"Ribot J. C.","journal-title":"J. Immunol"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6852"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00382.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.10.5814"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.10.012"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.655"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1449"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0213OC"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.025"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071978"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838475"},{"key":"e_1_2_7_63_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1172\/JCI38702","article-title":"IL\u201017 produced by neutrophils regulates IFN\u2010gamma\u2010mediated neutrophil migration in mouse kidney ischemia\u2010reperfusion injury","volume":"120","author":"Li L.","journal-title":"J. Clin. Invest"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22725"},{"key":"e_1_2_7_65_1","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.4049\/jimmunol.142.9.3239","article-title":"Characterization of granuloma T lymphocyte function from \n Schistosoma mansoni\u2010infected mice","volume":"142","author":"Ragheb S.","year":"1989","journal-title":"J. Immunol."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201141933","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201141933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T07:32:07Z","timestamp":1697527927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201141933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/eji.201141933"],"URL":"https:\/\/doi.org\/10.1002\/eji.201141933","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}