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Here we show that Strongy\u2010Ioides ratti, a gut\u2010dwelling nematode that causes transient infections, did not change the efficacy of vaccination against Plasmodium berghei. An ongoing infection with Litomosoides sigmodontis, a tissue\u2010dwelling filaria that induces chronic infections in BALB\/c mice, significantly interfered with vaccination efficacy. The induction of P. berghei circumspor\u2010ozoite protein (CSP)\u2010specific CD8<jats:sup>+<\/jats:sup> T cells, achieved by a single immunization with a CSP fusion protein, was diminished in L. sigmodontis\u2010infected mice. This modulation was reflected by reduced frequencies of CSP\u2010specific CD8<jats:sup>+<\/jats:sup> T cells, reduced CSP\u2010specific IFN\u2010y and TNF\u2010a production, reduced CSP\u2010specific cytotoxicity, and reduced protection against P. berghei challenge infection. Implementation of a more potent vaccine regime, by first priming with CSP\u2010expressing recombinant live Salmonella prior to CSP fusion protein immunization, restored induction of CSP\u2010specific CD8<jats:sup>+<\/jats:sup> T cells and conferred almost sterile immunity to P. berghei challenge infection also in L. sigmodontis\u2010infected mice. 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