{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:34:00Z","timestamp":1791401640895,"version":"4.3.3"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ)"},{"name":"Programa Estrat\u00e9gico de Apoio \u00e0 Pesquisa em Sa\u00fade (PAPES)\/Conselho de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Herein, we provide evidence that during allergic inflammation, CCL25 induces the selec\u2010tive migration of IL\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4 T cells mediated by \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub> integrin. Intrapleural injection of CCL25 into ovalbumin (OVA)\u2010immunized C57BL\/6 mice triggered the accumulation of \u03b3\u03b4 T lymphocytes expressing CCR9 (CCL25 receptor) and \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub> integrin in the pleura, but failed to attract \u03b1\u03b2 T lymphocytes. CCL25 attracted CCR6<jats:sup>+<\/jats:sup> \u03b3\u03b4 T cells producing IL\u201017 (but not IFN\u2010\u03b3 or IL\u20104). OVA challenge triggered increased production of CCL25 followed by the accumulation of CCR9<jats:sup>+<\/jats:sup>, \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub><jats:sup>+<\/jats:sup>, and CCR6<jats:sup>+<\/jats:sup>\/IL\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4 T cells into the pleural cavities of OVA\u2010immunized mice, which was inhibited by the in vivo neutralization of CCL25. The in vivo blockade of \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub> integrin also inhibited the migration of IL\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4 T lymphocytes (but not of \u03b1\u03b2 T lymphocytes) into mouse pleura after OVA challenge, suggesting that the CCL25\/\u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub> integrin pathway is selective for \u03b3\u03b4 T cells. In addition, \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub> integrin blockade impaired the in vitro transmigration of \u03b3\u03b4 T cells across endothelium (which expresses \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub> ligands VCAM\u20101 and MadCAM\u20101), which was induced by CCL25 and by cell\u2010free pleural washes recovered from OVA\u2010challenged mice. Our results reveal that during an allergic reaction, CCL25 drives IL\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4 T\u2010cell mobilization to inflamed tissue via \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>7<\/jats:sub> integrin and modulates IL\u201017 levels.<\/jats:p>","DOI":"10.1002\/eji.201142021","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T18:49:03Z","timestamp":1335466143000},"page":"1250-1260","source":"Crossref","is-referenced-by-count":30,"title":["CCL25 induces \u03b1<sub>4<\/sub>\u03b2<sub>7<\/sub> integrin\u2010dependent migration of IL\u201017<sup>+<\/sup>\u03b3\u03b4 T lymphocytes during an allergic reaction"],"prefix":"10.1002","volume":"42","author":[{"given":"Maria F. S.","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor U.","family":"Bornstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 L.","family":"Cand\u00e9a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Henriques\u2010Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Henriques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Penido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.975"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri797"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2008.20"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.12.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939922"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65449-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.22.2.3620"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01561.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.3170"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm128"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.06.040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.08.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.117481"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.6.2811"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1206726"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00266.2007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.085"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00167.2003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051100"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01726"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002620100190"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.4970"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.4049\/jimmunol.155.3.1117","article-title":"A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes V\u03b41+ \u03b3\u03b4 T cell adherence and tissue retention","volume":"155","author":"Nakajima S.","year":"1995","journal-title":"J. Immunol."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2626"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.26.4.4613"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.3293"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.08.031"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01090.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64888-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041645"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.10.6501"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.4914"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.214"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-303339"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.9.1241"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/314844"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0207125"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0407263"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1145"},{"key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.4049\/jimmunol.156.7.2558","article-title":"Cytokine\u2010regulated xpression of E\u2010selectin, intercellular adhesion molecule\u20101 (ICAM\u20101), and ascular cell adhesion molecule\u20101 (VCAM\u20101) in human microvascular endothelial cells","volume":"156","author":"Haraldsen G.","year":"1996","journal-title":"J. Immunol."},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.4.L813"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.04.022"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5940"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334995"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.04.018"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1717"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.001"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002283"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4466"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903942"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0408234"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900465"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.040"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200904-0573OC"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803828"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4832"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021978"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040773"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100269"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1461"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.013"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2893"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060285"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200911-1775OC"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2003-0266OC"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201142021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201142021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T16:14:41Z","timestamp":1698768881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201142021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,26]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/eji.201142021"],"URL":"https:\/\/doi.org\/10.1002\/eji.201142021","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,26]]}}}