{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:14:30Z","timestamp":1784682870331,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["MEST-CT-2005-020872"],"award-info":[{"award-number":["MEST-CT-2005-020872"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["K2007-58X-13027"],"award-info":[{"award-number":["K2007-58X-13027"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["K2010-56X-14588-08-3"],"award-info":[{"award-number":["K2010-56X-14588-08-3"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["K2010-79X-21374-01-3"],"award-info":[{"award-number":["K2010-79X-21374-01-3"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"Synergistic interplay between M<\/jats:styled-content>ycobacterium tuberculosis<\/jats:italic> (M<\/jats:styled-content>tb) and HIV in coinfected ind\u2010ividuals leads to the acceleration of both tuberculosis and HIV<\/jats:styled-content>disease. M<\/jats:styled-content>tb, as well as HIV<\/jats:styled-content>, may modulate the function of many immune cells, including DCs. To dissect the bystander impact of M<\/jats:styled-content>\u03c6s infected with M<\/jats:styled-content>tb on DC<\/jats:styled-content> functionality, we here investigated changes in DC<\/jats:styled-content> phenotype, cytokine profiles, and HIV<\/jats:styled-content>\u20101 transinfecting ability. An in vitro system was used in which human monocyte\u2010derived DC<\/jats:styled-content>s were exposed to soluble factors released by M<\/jats:styled-content>\u03c6s infected with mycobacteria, including virulent clinical M<\/jats:styled-content>tb isolates and nonvirulent BCG. Soluble factors secreted from M<\/jats:styled-content>tb\u2010infected M<\/jats:styled-content>\u03c6s, and to a lesser extent BCG<\/jats:styled-content>\u2010infected M<\/jats:styled-content>\u03c6s, resulted in the production of proinflammatory cytokines and partial upregulation of DC<\/jats:styled-content> maturation markers. Interestingly, the HIV<\/jats:styled-content>\u20101 transinfecting ability of DC<\/jats:styled-content>s was enhanced upon exposure to soluble factors released by M<\/jats:styled-content>tb\u2010infected M<\/jats:styled-content>\u03c6s. In summary, our study shows that DC<\/jats:styled-content>s exposed to soluble factors released by mycobacteria\u2010infected M<\/jats:styled-content>\u03c6s undergo maturation and display an augmented ability to transmit HIV<\/jats:styled-content>\u20101 in trans. These findings highlight the important role of bystander effects during the course of M<\/jats:styled-content>tb\u2013HIV<\/jats:styled-content> coinfection and suggest that M<\/jats:styled-content>tb\u2010infected M<\/jats:styled-content>\u03c6s may contribute to an environment that supports DC<\/jats:styled-content>\u2010mediated spread and amplification of HIV<\/jats:styled-content> in coinfected individuals.<\/jats:p>","DOI":"10.1002\/eji.201142049","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T18:49:03Z","timestamp":1335466143000},"page":"1192-1202","source":"Crossref","is-referenced-by-count":7,"title":["Mycobacteria\u2010infected bystander macrophages trigger maturation of dendritic cells and enhance their ability to mediate HIV<\/scp> transinfection"],"prefix":"10.1002","volume":"42","author":[{"given":"Jolanta","family":"Mazurek","sequence":"first","affiliation":[{"name":"Department of Microbiology Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"},{"name":"Swedish Institute for Infectious Disease Control Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lech","family":"Ignatowicz","sequence":"additional","affiliation":[{"name":"Department of Microbiology Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"},{"name":"Swedish Institute for Infectious Disease Control Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"K\u00e4llenius","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Microbiology Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Laboratory Medicine Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Pawlowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/651492"},{"key":"e_1_2_7_3_1","first-page":"550","article-title":"HIV\u2010TB co\u2010infection: epidemiology, diagnosis & management","volume":"121","author":"Sharma S. K.","year":"2005","journal-title":"Indian J. Med. Res."},{"key":"e_1_2_7_4_1","first-page":"316","article-title":"Extrapulmonary tuberculosis","volume":"120","author":"Sharma S. K.","year":"2004","journal-title":"Indian J. Med. Res."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.00758.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2006.00192.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04269.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00106-10"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.753-777.2001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/378676"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.3.405"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002810000053"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2000.00888.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1352913"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-06508-2_1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8895"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-51"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80694-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0503208"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1417"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1778"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(03)00027-3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945008783502467"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1939"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007654108"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920306778017990"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2004.05.012"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(06)93007-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200701-026AW"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2509"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1128\/jcm.30.9.2415-2418.1992","article-title":"Detection of lipoarabinomannan as a diagnostic test for tuberculosis","volume":"30","author":"Sada E.","year":"1992","journal-title":"J. Clin. Microbiol."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(01)00239-1"},{"key":"e_1_2_7_35_1","first-page":"125","article-title":"Isolation and analysis of circulating tuberculous antigens in Mycobacterium tuberculosis","volume":"54","author":"Shende N.","year":"2007","journal-title":"Indian J. Tuberc."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.01.009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006116"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsymp.5650031"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2228"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7033"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.11.6580-6587.2001"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1162"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02572-06"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2005.00293.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.4.587"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00878-07"},{"key":"e_1_2_7_47_1","first-page":"38","article-title":"Dendritic cell infection, depletion and dysfunction in HIV\u2010infected individuals","volume":"71","author":"Macatonia S. E.","year":"1990","journal-title":"Immunology"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/08892220152596623"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0503204"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-5-28"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1858"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02303-09"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1996"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090254"},{"key":"e_1_2_7_55_1","first-page":"1267","article-title":"Circulating cytokines in pulmonary tuberculosis according to HIV status and dietary iron content","volume":"13","author":"Gordeuk V. R","year":"2009","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_2_7_56_1","first-page":"239","article-title":"Use of DNA fingerprinting in international source case finding during a large outbreak of tuberculosis in The Netherlands","volume":"1","author":"Kiers A.","year":"1997","journal-title":"Int. J. Tuberc Lung Dis."},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.03.006"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016647"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.26.15382"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.10.7478-7487.1997"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201142049","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201142049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T16:14:13Z","timestamp":1698768853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201142049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,26]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/eji.201142049"],"URL":"https:\/\/doi.org\/10.1002\/eji.201142049","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,26]]}}}