{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:41:59Z","timestamp":1791052919740,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:00:00Z","timestamp":1324339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two subsets of CD8<jats:sup>+<\/jats:sup> T cells are generated early during an immune response; one of these subsets forms the memory pool, known as memory precursor effector cells (MPECs), identified by high expression of CD127 and low expression of KLRG1, whereas the other subset forms short\u2010lived effector cells (SLECs) identified by low expression of CD127 and high expression of KLRG1. Here, we studied in vivo the role of type\u2010I IFN in this fate decision. We found that under priming conditions dominated by type\u2010I IFN, as observed in lymphocytic choriomeningitis virus (LCMV) infection, type\u2010I IFN signaling directly impacted the regulation of T\u2010bet and thus the early fate decision of CD8<jats:sup>+<\/jats:sup> T cells. In the absence of type\u2010I IFN signaling, CD8<jats:sup>+<\/jats:sup> T cells failed to form SLECs but could form MPECs that give rise to functional memory CD8<jats:sup>+<\/jats:sup> T cells. Together, these findings identify type\u2010I IFN as an important factor driving SLEC differentiation and thus instructing the early division between the effector and memory precursor CD8<jats:sup>+<\/jats:sup> T\u2010cell pool.<\/jats:p>","DOI":"10.1002\/eji.201142091","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T10:13:22Z","timestamp":1321870402000},"page":"320-329","source":"Crossref","is-referenced-by-count":83,"title":["Type\u2010I IFN drives the differentiation of short\u2010lived effector CD8<sup>+<\/sup> T cells in vivo"],"prefix":"10.1002","volume":"42","author":[{"given":"Melanie","family":"Wiesel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Crouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Bedenikovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Joller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Oxenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.01.088"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.010"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200839093"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5521"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.5165"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021910"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900592"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803484"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.4049\/jimmunol.162.6.3256","article-title":"Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+T cells","volume":"162","author":"Curtsinger J. M.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni978"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2074"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802982"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.010"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.012"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003166"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4525"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050821"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.3.1746"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81408-7"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141537"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001990"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1268"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00895.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.05.008"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00901.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.10.010"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040873"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913729107"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081242"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002042"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090148"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909945107"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000492"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4465"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.8.1315"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011672"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03412.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.5935"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7515"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/346629a0"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201142091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201142091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:27:51Z","timestamp":1697462871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201142091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,20]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/eji.201142091"],"URL":"https:\/\/doi.org\/10.1002\/eji.201142091","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,20]]}}}