{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:44:17Z","timestamp":1791999857367,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Because of their plasticity and central role in orchestrating immunity and tolerance, <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s can respond to pregnancy\u2010specific signals, thus promoting the appropriate immune response in order to support pregnancy. Here, we show that pregnancy\u2010specific glycoprotein (<jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>1a), the major variant of <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content> released into the circulation during pregnancy, targets <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s to differentiate into a subset with a unique phenotype and function. This semi\u2010mature phenotype is able to secrete <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2. <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>1a also affected the maturation of <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s, preventing the up\u2010regulation of some costimulatory molecules, and inducing the secretion of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 or <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 and the expression of programmed death ligand 1 (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>1) in response to <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u20109 or <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40 ligation. In addition, <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>1a\u2010treated <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s promoted the enrichment of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2\u2010type cytokines, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\u2010producing cells, and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells from <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells from <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content>11.10 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>g mice. Moreover, in vivo expression of <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>1a promoted the expansion of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g\u2010specific <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>oxp3<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\u2010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104\u2010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105\u2010, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010\u2010secreting cells able to protect against <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>isteria monocytogenes<\/jats:italic> infection. Taken together, our data indicate that <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s can be targeted by <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>1a to generate the signals necessary to mount an appropriate, well\u2010balanced, and effective immune response able to protect against invading pathogens while at the same time being compatible with a successful pregnancy.<\/jats:p>","DOI":"10.1002\/eji.201142140","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T11:28:19Z","timestamp":1339154899000},"page":"1573-1584","source":"Crossref","is-referenced-by-count":43,"title":["Pregnancy\u2010specific glycoprotein 1a activates dendritic cells to provide signals for <scp>T<\/scp>h17\u2010, <scp>T<\/scp>h2\u2010, and <scp>T<\/scp>reg\u2010cell polarization"],"prefix":"10.1002","volume":"42","author":[{"given":"Fernando F.","family":"Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina P.","family":"Knubel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cervi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia C.","family":"Motr\u00e1n","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI\u2010CONICET) Departamento de Bioqu\u00edmica Cl\u00ednica Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1443"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072665"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216109"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.2.229"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90235-D"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.9.4562"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00852.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/S0021-9258(19)77983-6","article-title":"Isolation and characterization of complementary DNAs encoding human pregnancy\u2010specific beta 1\u2010glycoprotein","volume":"263","author":"Watanabe S.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb08899.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)90075-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1981.tb00999.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02570647"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.3.512"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323993"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2001.450403.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<1830::AID-IMMU1830>3.0.CO;2-M"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.4049\/jimmunol.160.12.6046","article-title":"Th1 cells specific for a secreted protein of Listeria monocytogenes are protective in vivo","volume":"160","author":"Geginat G.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01393-0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0804453"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.07.011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.082412"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.070268"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00848.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.010058"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050019"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.022640"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.3.461"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.9.4457"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090847"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.01.020"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.018"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838137"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.10.006"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.001"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200635840"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040979"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803402"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2004.04.009"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00019405"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1539"},{"key":"e_1_2_7_46_1","first-page":"2062","article-title":"Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal\/fetal interface in mice","volume":"119","author":"Collins M.","year":"2009","journal-title":"J. Clin. Invest."},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00366.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(98)00204-X"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3402"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201142140","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201142140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T07:32:31Z","timestamp":1697527951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201142140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/eji.201142140"],"URL":"https:\/\/doi.org\/10.1002\/eji.201142140","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}