{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:39:58Z","timestamp":1765485598747},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:00:00Z","timestamp":1342483200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1 is a negative regulator of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell activation factor of the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> family (<jats:styled-content style=\"fixed-case\">BAFF)<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010induced signaling. BALB\/C mice lacking <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1 develop systemic autoimmunity resembling systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>j\u00f6gren's syndrome (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>j<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>j<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> are characterized by anti\u2010nuclear <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> autoantibody (<jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>) production and inflammation of peripheral tissues. As autoantibody production can occur in a <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell dependent or <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell independent manner, we investigated the role of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell help during <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1\u2010mediated autoimmunity. <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1\u2010deficiency was bred onto <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>57<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>l\/6 (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6.<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1<jats:sup>\u2212\/\u2212<\/jats:sup>) mice and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6.<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u03b2<jats:sup>\u2212\/\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1<jats:sup>\u2212\/\u2212<\/jats:sup> (<jats:styled-content style=\"fixed-case\">TKO<\/jats:styled-content>) mice were generated. While <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u03b2\/\u03b4\u2010sufficient <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6.<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1<jats:sup>\u2212\/\u2212<\/jats:sup> mice developed splenomegaly and lymphadenopathy, hypergammaglobulinemia, elevated levels of <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>, and kidney pathology, <jats:styled-content style=\"fixed-case\">TKO<\/jats:styled-content> mice failed to develop any such signs of disease. Neither <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6.<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1<jats:sup>\u2212\/\u2212<\/jats:sup> nor <jats:styled-content style=\"fixed-case\">TKO<\/jats:styled-content> mice developed <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>j<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\u2010like disease, suggesting that epigenetic interactions on the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ALB\/C background are responsible for this phenotype in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ALB\/C.<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Interestingly, <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content>\u2010driven transitional <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell abnormalities, previously reported in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ALB\/C.<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1<jats:sup>\u2212\/\u2212<\/jats:sup> mice, were intact in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6.<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1<jats:sup>\u2212\/\u2212<\/jats:sup> mice and largely independent of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells. In conclusion, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells are necessary for the development of <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>\u2010like disease in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6.<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ct1<jats:sup>\u2212\/\u2212<\/jats:sup> mice, but not <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content>\u2010driven transitional <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell differentiation.<\/jats:p>","DOI":"10.1002\/eji.201142238","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T12:46:09Z","timestamp":1336999569000},"page":"1695-1705","source":"Crossref","is-referenced-by-count":11,"title":["Lack of <scp>T<\/scp> cells in <scp>A<\/scp>ct1\u2010deficient mice results in elevated <scp>I<\/scp>g<scp>M<\/scp>\u2010specific autoantibodies but reduced lupus\u2010like disease"],"prefix":"10.1002","volume":"42","author":[{"given":"Angela C.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Davison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V.","family":"Giltiay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chairut","family":"Vareechon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine N.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Immunology NE40, Lerner Research Institute Cleveland Clinic Foundation Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.09.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903312"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1697"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.5.615"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.1.9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.04.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005456"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738113"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.09.015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90095-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90073-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00782.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/369654a0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260729"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35010115"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni829"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062567"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1914"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00389-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011691"},{"key":"e_1_2_7_22_1","unstructured":"2001 Mosby International Limited B. L. Kotzin S. G. West R. Rich W. T. Shearer B. L. Kotzin H. W. Schroeder Systemic Lupus Erythrematosus 60.1 60.24"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.812"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020243"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.1.75"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.10.1453"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem097"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2007.02049.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.11.7770"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.1.27"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1886"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011453"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.017"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002176"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.8.1175"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.10.1453"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061964"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1741"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364430"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201142238","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201142238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:55:41Z","timestamp":1697504141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201142238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1002\/eji.201142238"],"URL":"https:\/\/doi.org\/10.1002\/eji.201142238","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}