{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:05:04Z","timestamp":1792325104102,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T00:00:00Z","timestamp":1341792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"Retinoic acid related orphan receptor gamma\u2010t (ROR<\/jats:styled-content>\u03b3t) is known to be a master regulator of T<\/jats:styled-content>h17\u2010cell development. In this study, we generated ROR<\/jats:styled-content>\u03b3t\u2010overexpressing transgenic (ROR<\/jats:styled-content>\u03b3t T<\/jats:styled-content>g) mice in which transgene expression was driven by the CD<\/jats:styled-content>2 promoter, and found that these mice developed polyclonal plasmacytosis and autoantibody production. ROR<\/jats:styled-content>\u03b3t T<\/jats:styled-content>g mice were generated on a C<\/jats:styled-content>57BL<\/jats:styled-content>\/6 background, and also were intercrossed with B<\/jats:styled-content>ALB\/c mice. B<\/jats:styled-content>ALB\/c F<\/jats:styled-content>1 (B<\/jats:styled-content>ALB\/F<\/jats:styled-content>1) ROR<\/jats:styled-content>\u03b3t T<\/jats:styled-content>g mice developed massive polyclonal plasma\u2010cytosis, and had shorter life spans. Splenomegaly and infiltration of plasma cells into the lung were observed. Hyperglobulinemia, anti\u2010double\u2010stranded DNA<\/jats:styled-content> antibodies, anti\u2010erythrocyte antibodies, and anti\u2010platelet antibodies were detected in B<\/jats:styled-content>ALB\/F<\/jats:styled-content>1 ROR<\/jats:styled-content>\u03b3t T<\/jats:styled-content>g mice. In the present study, polyclonal plasmacytosis in B<\/jats:styled-content>ALB\/F<\/jats:styled-content>1 ROR<\/jats:styled-content>\u03b3t T<\/jats:styled-content>g mice appeared to be due to the induction of excessive IL<\/jats:styled-content>\u20106 production by IL<\/jats:styled-content>\u201017. We detected increased numbers of CD<\/jats:styled-content>11b+<\/jats:sup> cells that produced IL<\/jats:styled-content>\u20106. We also generatedIL<\/jats:styled-content>\u20106\u2010deficient ROR<\/jats:styled-content>\u03b3t T<\/jats:styled-content>g B<\/jats:styled-content>ALB\/F<\/jats:styled-content>1 background mice, which displayed high levels of serum IL<\/jats:styled-content>\u201017, but did not develop severe hyperglobulinemia. Excessive IL<\/jats:styled-content>\u20106 production by several cell types, including macrophages, in B<\/jats:styled-content>ALB\/F<\/jats:styled-content>1 ROR<\/jats:styled-content>\u03b3t T<\/jats:styled-content>g mice, might effect the development of plasma\u2010cytosis. These results suggest that ROR<\/jats:styled-content>\u03b3t plays important roles in the development of plasmacytosis and autoantibody production.<\/jats:p>","DOI":"10.1002\/eji.201142250","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T15:25:05Z","timestamp":1337786705000},"page":"1999-2009","source":"Crossref","is-referenced-by-count":27,"title":["Overexpression of ROR<\/scp>\u03b3t under control of the CD<\/scp>2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice"],"prefix":"10.1002","volume":"42","author":[{"given":"Keigyou","family":"Yoh","sequence":"first","affiliation":[{"name":"Department of Nephrology Faculty of Medicine University of Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Morito","sequence":"additional","affiliation":[{"name":"Department of Nephrology Faculty of Medicine University of Tsukuba Ibaraki 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