{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:04:29Z","timestamp":1791353069341,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Intravenous immunoglobulin <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g) therapy is widely used to treat autoimmune and inflammatory diseases. Recent evidence suggests that in mice, splenic resident cells might be important for the anti\u2010inflammatory activity of <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g in a model of serum transfer arthritis. Splenectomized human immunothrombocytopenia (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>) patients, however, still respond to <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g therapy. To investigate whether the requirement of the spleen is essential for mouse <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>, we used a passive model of induced <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> and demonstrated that <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g activity was functional in splenectomized animals. Further analysis showed that the <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g\u2010mediated amelioration of platelet phagocytosis was fully dependent on terminal sialic acid residues in the <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g preparation and could be blocked with a specific <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>3 grabbing nonintegrin\u2010related 1 (<jats:styled-content style=\"fixed-case\">SIGNR<\/jats:styled-content>1) specific antibody. These results suggest that, similar to the human system, a spleen\u2010independent but sialic acid\u2010 and <jats:styled-content style=\"fixed-case\">SIGNR<\/jats:styled-content>1\u2010dependent pathway is responsible for <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g\u2010mediated suppression of autoantibody\u2010dependent platelet depletion in mice.<\/jats:p>","DOI":"10.1002\/eji.201142260","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T11:02:10Z","timestamp":1327575730000},"page":"826-830","source":"Crossref","is-referenced-by-count":108,"title":["<scp>IVI<\/scp>g\u2010mediated amelioration of <scp>ITP<\/scp> in mice is dependent on sialic acid and <scp>SIGNR<\/scp>1"],"prefix":"10.1002","volume":"42","author":[{"given":"Inessa","family":"Schwab","sequence":"first","affiliation":[{"name":"Institute of Genetics, Department of Biology University of Erlangen\u2010N\u00fcrnberg Erlangen 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