{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:06:28Z","timestamp":1791331588689,"version":"4.3.1"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T00:00:00Z","timestamp":1354665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI042265-13"],"award-info":[{"award-number":["AI042265-13"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"\n CD<\/jats:styled-content>\n 19\u2010deficient mice were used as a model to study follicular dendritic cell (\n FDC<\/jats:styled-content>\n ) activation because these mice have normal numbers of\n FDC<\/jats:styled-content>\n \u2010containing primary follicles, but lack the ability to activate\n FDC<\/jats:styled-content>\n s or form\n GC<\/jats:styled-content>\n s. It was hypothesized that\n CD<\/jats:styled-content>\n 19 expression is necessary for\n B<\/jats:styled-content>\n \u2010cell activation and upregulation of membrane lymphotoxin (m\n LT<\/jats:styled-content>\n ) expression, which promotes\n FDC<\/jats:styled-content>\n activation. Using\n VCAM<\/jats:styled-content>\n \u20101 and\n F<\/jats:styled-content>\n c\u03b3\n R<\/jats:styled-content>\n II\/III as\n FDC<\/jats:styled-content>\n activation markers, it was determined that the adoptive transfer of\n CD<\/jats:styled-content>\n 19\n +<\/jats:sup>\n wild\u2010type\n B<\/jats:styled-content>\n cells into\n CD<\/jats:styled-content>\n 19\u2010deficient hosts rescued\n GC<\/jats:styled-content>\n formation and\n FDC<\/jats:styled-content>\n activation, demonstrating that\n CD<\/jats:styled-content>\n 19 expression on\n B<\/jats:styled-content>\n cells is required for\n FDC<\/jats:styled-content>\n activation. In contrast,\n CD<\/jats:styled-content>\n 19\n +<\/jats:sup>\n donor\n B<\/jats:styled-content>\n cells lacking m\n LT<\/jats:styled-content>\n were unable to induce\n VCAM<\/jats:styled-content>\n \u20101 expression on\n FDC<\/jats:styled-content>\n s, furthermore\n F<\/jats:styled-content>\n c\u03b3\n R<\/jats:styled-content>\n II\/III upregulation was impaired in\n FDC<\/jats:styled-content>\n s stimulated with m\n LT<\/jats:styled-content>\n \u2010deficient\n B<\/jats:styled-content>\n cells.\n VCAM<\/jats:styled-content>\n \u20101 expression on\n FDC<\/jats:styled-content>\n s, but not\n F<\/jats:styled-content>\n c\u03b3\n R<\/jats:styled-content>\n II\/III, was rescued when\n CD<\/jats:styled-content>\n 19\u2010deficient\n B<\/jats:styled-content>\n cells expressing transgenic m\n LT<\/jats:styled-content>\n were cotransferred into recipient mice with\n CD<\/jats:styled-content>\n 19\n +<\/jats:sup>\n , m\n LT<\/jats:styled-content>\n \u2010deficient\n B<\/jats:styled-content>\n cells, suggesting that\n FDC<\/jats:styled-content>\n activation requires the\n CD<\/jats:styled-content>\n 19\u2010dependent upregulation of m\n LT<\/jats:styled-content>\n on activated\n B<\/jats:styled-content>\n cells. Collectively, these data demonstrate that activated\n B<\/jats:styled-content>\n cells are responsible for the initiation of\n FDC<\/jats:styled-content>\n activation resulting in a microenvironment supportive of\n GC<\/jats:styled-content>\n development and maintenance.\n <\/jats:p>","DOI":"10.1002\/eji.201242471","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T05:21:08Z","timestamp":1351574468000},"page":"348-359","source":"Crossref","is-referenced-by-count":31,"title":["Lymphotoxin \u03b1\n 1<\/sub>\n \u03b2\n 2<\/sub>\n expression on\n B<\/scp>\n cells is required for follicular dendritic cell activation during the germinal center response"],"prefix":"10.1002","volume":"43","author":[{"given":"Riley C.","family":"Myers","sequence":"first","affiliation":[{"name":"Department of Microbiology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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