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Here, we show that levels of IL\u201027p28 transcript and protein were both significantly elevated in patients with sepsis, particularly melioidosis and in patients with unfavorable disease outcome. Moreover, human monocytes\/macrophages and neutrophils were the major source of IL\u201027 during infection. The addition of exogenous IL\u201027 in vitro resulted in significantly increased bacterial survival, reduced <jats:italic>B. pseudomallei<\/jats:italic>\u2010induced oxidative burst, and enhanced IL\u20101\u03b2 and TNF\u2010\u03b1 production by purified neutrophils from healthy subjects. Finally, blockade of endogenous IL\u201027 in neutrophils using soluble IL\u201027 receptor antagonist prior to infection led to significantly reduced survival of bacteria and decreased IL\u20101\u03b2, but not TNF\u2010\u03b1 production. These results indicate a potential role for IL\u201027 in the suppression of anti\u2010bacterial defense mechanisms that might contribute to disease severity in sepsis. The targeting of this cytokine may be beneficial in the management of human sepsis.<\/jats:p>","DOI":"10.1002\/eji.201242526","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T06:55:28Z","timestamp":1347346528000},"page":"3280-3290","source":"Crossref","is-referenced-by-count":31,"title":["Production of interleukin\u201027 by human neutrophils regulates their function during bacterial infection"],"prefix":"10.1002","volume":"42","author":[{"given":"Darawan","family":"Rinchai","sequence":"first","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL) Faculty of Associated Medical Sciences Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasong","family":"Khaenam","sequence":"additional","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL) Faculty of Associated Medical Sciences Khon Kaen University Khon Kaen Thailand"},{"name":"Benaroya Research Institute Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidchamai","family":"Kewcharoenwong","sequence":"additional","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL) Faculty of Associated Medical Sciences Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surachat","family":"Buddhisa","sequence":"additional","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL) Faculty of Associated Medical Sciences Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungnapa","family":"Pankla","sequence":"additional","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL) Faculty of Associated Medical Sciences Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Chaussabel","sequence":"additional","affiliation":[{"name":"Benaroya Research Institute Seattle WA USA"},{"name":"Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense Baylor Institute for Immunology Research (BIIR) Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Bancroft","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection London School of Hygiene &amp; 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