{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:58:27Z","timestamp":1778943507810,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labour Sciences Research","award":["H22-011"],"award-info":[{"award-number":["H22-011"]}]},{"DOI":"10.13039\/100007416","name":"Japan Health Sciences Foundation","doi-asserted-by":"crossref","award":["KHA1002"],"award-info":[{"award-number":["KHA1002"]}],"id":[{"id":"10.13039\/100007416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"crossref","award":["22A-5"],"award-info":[{"award-number":["22A-5"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Young Scientists","award":["23791211"],"award-info":[{"award-number":["23791211"]}]},{"DOI":"10.13039\/501100007077","name":"National Institute of Biomedical Innovation","doi-asserted-by":"crossref","award":["10-45"],"award-info":[{"award-number":["10-45"]}],"id":[{"id":"10.13039\/501100007077","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"We previously identified zinc finger (ZF<\/jats:styled-content>) protein ZNF<\/jats:styled-content>385B<\/jats:styled-content> as a molecule specifically expressed in B<\/jats:styled-content>urkitt's lymphoma (BL<\/jats:styled-content>) among hematologic malignancies. Here, we investigated ZNF<\/jats:styled-content>385B<\/jats:styled-content> expression in healthy B<\/jats:styled-content> cells in a variety of hematological tissues by RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content> and immunohistochemistry. ZNF<\/jats:styled-content>385B<\/jats:styled-content> expression was found to be limited to a subset of GC B<\/jats:styled-content> cells, the healthy counterpart to BL B<\/jats:styled-content> cells. To elucidate the function of ZNF<\/jats:styled-content>385B<\/jats:styled-content> in healthy B<\/jats:styled-content> cells, we established a tetracycline\u2010controlled protein\u2010inducible system in B<\/jats:styled-content>\u2010cell lines and observed that ectopic expression of the longest transcript variant of ZNF<\/jats:styled-content>385B<\/jats:styled-content>, possessing four ZF<\/jats:styled-content> domains, induced upregulation of PERP<\/jats:styled-content><\/jats:italic> and FAS<\/jats:styled-content>\/CD<\/jats:styled-content>95<\/jats:italic>, a downstream target of p53, and activation of caspase, resulting in apoptosis induction. However, a ZNF<\/jats:styled-content>385B<\/jats:styled-content> deletion mutant with three ZF<\/jats:styled-content> domains corresponding to shorter isoforms, did not induce upregulation; rather it inhibited apoptosis induced by CD<\/jats:styled-content>20 cross\u2010linking and BCR<\/jats:styled-content> stimulation. The direct binding of ZNF<\/jats:styled-content>385B<\/jats:styled-content> with p53 has suggested the involvement of ZNF<\/jats:styled-content>385B<\/jats:styled-content> in B<\/jats:styled-content>\u2010cell apoptosis via modulation of p53 transactivation; our data indicate that ZNF<\/jats:styled-content>385B<\/jats:styled-content> characteristically expressed in GC B<\/jats:styled-content> cells has both proapoptotic and antiapoptotic activities depending on the type of isoform and should be a novel player in GC B<\/jats:styled-content>\u2010cell selection.<\/jats:p>","DOI":"10.1002\/eji.201242530","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T10:21:28Z","timestamp":1346754088000},"page":"3405-3415","source":"Crossref","is-referenced-by-count":18,"title":["ZNF<\/scp>385B<\/scp> is characteristically expressed in germinal center B<\/scp> cells and involved in B<\/scp>\u2010cell apoptosis"],"prefix":"10.1002","volume":"42","author":[{"given":"Kazutoshi","family":"Iijima","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Miharu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken\u2010Ichi","family":"Imadome","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"},{"name":"Department of Microbiology and Molecular Genetics University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology National Medical Center for Children and Mothers Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyoshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Director of Clinical Research Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Kiyokawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1900"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050552997"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.04.040186.003201"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4049\/jimmunol.139.1.313","article-title":"Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)\u2010like phenotype","volume":"139","author":"Gregory C. 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