{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:59:13Z","timestamp":1791248353434,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Regional Government of Flanders"},{"name":"Belgian Federal Government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Following immunization with collagen II (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>II) in complete <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>reund's adjuvant (<jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">DBA<\/jats:styled-content>\/1 mice develop arthritis of major joints. This collagen\u2010induced arthritis (<jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content>) is used as a model for rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) in man. Inflammatory changes in lung tissue commonly occur in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. However, evidence for pulmonary inflammation in <jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content> is scarce and ambiguous. Here, we demonstrate pulmonary inflammation accompanying <jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content> in wild\u2010type <jats:styled-content style=\"fixed-case\">DBA<\/jats:styled-content>\/1 mice. In <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 receptor\u2010deficient (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:styled-content style=\"fixed-case\">R KO<\/jats:styled-content>) mice, inflammation was more frequent and more severe. Injection of <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content> only (without <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>II) proved to be as efficient in eliciting pulmonary inflammation as immunization with <jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>II, though being less effective in causing arthritis. Significant correlation in severity between joint and pulmonary involvement could not be demonstrated. Macroscopic, microscopic, and functional characteristics of pulmonary inflammation in the mice resembled those seen in human <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. Increased inflammation in <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:styled-content style=\"fixed-case\">R KO<\/jats:styled-content> mice was accompanied by augmented expression of various cytokines and chemokines, as measured by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> on affected tissue. Treatment with a <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 inhibitor ameliorated lung pathology. We conclude that <jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">DBA<\/jats:styled-content>\/1 mice is accompanied by pulmonary inflammation. Although both disease processes are kept in check by endogenous <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3, lack of strict parallelism indicates that overlap in their pathogeneses is partial.<\/jats:p>","DOI":"10.1002\/eji.201242573","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T06:01:33Z","timestamp":1346220093000},"page":"3223-3234","source":"Crossref","is-referenced-by-count":28,"title":["Pulmonary inflammation in mice with collagen\u2010induced arthritis is conditioned by complete <scp>F<\/scp>reund's adjuvant and regulated by endogenous <scp>IFN<\/scp>\u2010\u03b3"],"prefix":"10.1002","volume":"42","author":[{"given":"Evelien","family":"Schurgers","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiology Rega Institute, University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya","family":"Mertens","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology Rega Institute, University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen A. 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