{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:45:06Z","timestamp":1791423906624,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Education (PRIN)"},{"name":"Ente Cassa di Risparmio di Firenze, Associazione Italiana Ricerca sul Cancro (AIRC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"T<\/jats:styled-content> helper17 (T<\/jats:styled-content>h17) lymphocytes represent a third arm of the CD<\/jats:styled-content>4+<\/jats:sup> T<\/jats:styled-content>\u2010cell effector responses, in addition to T<\/jats:styled-content>h1 and T<\/jats:styled-content>h2 cells. T<\/jats:styled-content>h17 cells have been found to exhibit high plasticity because they rapidly shift into the T<\/jats:styled-content>h1 phenotype in inflammatory sites. In humans, T<\/jats:styled-content>h1 cells derived from T<\/jats:styled-content>h17 cells express CD<\/jats:styled-content>161, whereas classic T<\/jats:styled-content>h1 cells do not; these T<\/jats:styled-content>h17\u2010derived T<\/jats:styled-content>h1 cells have been termed nonclassic T<\/jats:styled-content>h1 cells. In this study, we examined similarities and differences between classic and nonclassic human T<\/jats:styled-content>h1 cells by assessing a panel of T<\/jats:styled-content>\u2010cell clones, as well as CD<\/jats:styled-content>161+<\/jats:sup> or CD<\/jats:styled-content>161\u2212<\/jats:sup> CD<\/jats:styled-content>4+<\/jats:sup> T<\/jats:styled-content> cells derived ex vivo from the circulation of healthy subjects or the synovial fluid of patients with juvenile idiopathic arthritis. The results show that nonclassic T<\/jats:styled-content>h1 cells can be identified based on CD<\/jats:styled-content>161 expression, as well as the consistent expression of retinoic acid orphan receptor C<\/jats:styled-content>, IL<\/jats:styled-content>\u201017 receptor E<\/jats:styled-content>, CCR<\/jats:styled-content>6, and IL<\/jats:styled-content>\u20104\u2010induced gene 1, which are all virtually absent in classic T<\/jats:styled-content>h1 cells. The possibility to distinguish these two\u2010cell subsets by using such a panel of markers may allow the opportunity to better establish the respective pathogenic roles of classic and nonclassic (T<\/jats:styled-content>h17 derived) T<\/jats:styled-content>h1 cells in different chronic inflammatory disorders.<\/jats:p>","DOI":"10.1002\/eji.201242648","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T06:55:29Z","timestamp":1347346529000},"page":"3180-3188","source":"Crossref","is-referenced-by-count":127,"title":["Distinctive features of classic and nonclassic (T<\/scp>h17 derived) human T<\/scp>h1 cells"],"prefix":"10.1002","volume":"42","author":[{"given":"Laura","family":"Maggi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and DENOTHE Center University of Florence Firenze 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