{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:20:22Z","timestamp":1792221622866,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:00:00Z","timestamp":1367452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Dysregulation of apoptosis caused by an imbalance of pro\u2010 and anti\u2010apoptotic protein expression can lead to cancer, neurodegenerative, and autoimmune diseases. Cellular\u2010FLIP (c\u2010FLIP) proteins inhibit apoptosis directly at the death\u2010inducing signaling complex of death receptors, such as CD95, and have been linked to apoptosis regulation during immune responses. While the isoforms c\u2010FLIP<jats:sub>L<\/jats:sub> and c\u2010FLIP<jats:sub>S<\/jats:sub> are well characterized, the function of c\u2010FLIP<jats:sub>R<\/jats:sub> remains poorly understood. Here, we demonstrate the induction of endogenous murine c\u2010FLIP<jats:sub>R<\/jats:sub> in activated lymphocytes for the first time. To analyze c\u2010FLIP<jats:sub>R<\/jats:sub> function in vivo<jats:italic>,<\/jats:italic> we generated transgenic mice expressing murine c\u2010FLIP<jats:sub>R<\/jats:sub> specifically in hematopoietic cells. As expected, lymphocytes from c\u2010FLIP<jats:sub>R<\/jats:sub> transgenic mice were protected against CD95\u2010induced apoptosis in vitro. In the steady state, transgenic mice had normal cell numbers and unaltered frequencies of B cells and T\u2010cell subsets in lymphoid organs. However, when challenged with <jats:italic>Listeria monocytogenes<\/jats:italic>, c\u2010FLIP<jats:sub>R<\/jats:sub> transgenic mice showed less liver necrosis and better bacterial clearance compared with infected wild\u2010type mice. We conclude that c\u2010FLIP<jats:sub>R<\/jats:sub> expression in hematopoietic cells supports an efficient immune response against bacterial infections.<\/jats:p>","DOI":"10.1002\/eji.201242819","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T19:55:19Z","timestamp":1363377319000},"page":"1499-1510","source":"Crossref","is-referenced-by-count":16,"title":["Cellular\u2010FLIP, Raji isoform (c\u2010FLIP<sub>R<\/sub>) modulates cell death induction upon T\u2010cell activation and infection"],"prefix":"10.1002","volume":"43","author":[{"given":"Tanja","family":"Telieps","sequence":"first","affiliation":[{"name":"Laboratory of Systems\u2010Oriented Immunology and Inflammation Research Institute of Molecular and Clinical Immunology Otto\u2010von\u2010Guericke\u2010University  Magdeburg Germany"},{"name":"Department of Immune Control Helmholtz Centre for Infection Research  Braunschweig 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