{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:26:53Z","timestamp":1781144813918,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p><jats:italic>Plasmodium spp<\/jats:italic>. parasites, the causative agents of malaria, survive and replicate in human hosts by modulating host protective immune responses. In a rodent model, malaria manifests as a severe splenomegaly, with infiltration of cells and lympho\u2010proliferation as major contributing factors of the immunopathology. However, the cellular contents and the functions of these cells have not been well studied. Here, we report that <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>lasmodium berghei<\/jats:italic> infection of mice leads to massive recruitment of mesen\u2010chymal stem cells (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s) in secondary lymphoid organs. Infusion of these cells into na\u00efve mice was able to confer host resistance against malaria. Furthermore, <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s augmented interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201012 production but suppressed <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 production in recipient animals. In addition, we observed dramatic reductions of regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg) cells in animals that received <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s. Taken together, our findings have identified recruitment of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s as a novel host protective mechanism adopted by the host to combat malaria by modulating <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg\u2010cell responses.<\/jats:p>","DOI":"10.1002\/eji.201242882","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T07:28:42Z","timestamp":1368516522000},"page":"2070-2077","source":"Crossref","is-referenced-by-count":37,"title":["Mesenchymal stem cells play an important role in host protective immune responses against malaria by modulating regulatory <scp>T<\/scp> cells"],"prefix":"10.1002","volume":"43","author":[{"given":"Reva S.","family":"Thakur","sequence":"first","affiliation":[{"name":"Immunology Division National Institute of Malaria Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Tousif","sequence":"additional","affiliation":[{"name":"Immunology Group International Centre for Genetic Engineering and Biotechnology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikky","family":"Awasthi","sequence":"additional","affiliation":[{"name":"Immunology Division National Institute of Malaria Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Immunology Division National Institute of Malaria Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. K.","family":"Atul","sequence":"additional","affiliation":[{"name":"Immunology Division National Institute of Malaria Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Punia","sequence":"additional","affiliation":[{"name":"Immunology Division National Institute of Malaria Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Das","sequence":"additional","affiliation":[{"name":"Immunology Division National Institute of Malaria Research  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,12]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization World malaria report 2011.http:\/\/www.who.int\/malaria\/world_malaria_report_2011\/en\/"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00261-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.08.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00775.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000402"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm975"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/339408"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01005-07"},{"key":"e_1_2_7_10_1","first-page":"1145","article-title":"Cytokines in the pathogenesis of and protection against malaria","volume":"9","author":"Angulo I.","year":"2002","journal-title":"Clin. 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Hyg."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201242882","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201242882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T23:55:50Z","timestamp":1696636550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201242882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,12]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/eji.201242882"],"URL":"https:\/\/doi.org\/10.1002\/eji.201242882","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,12]]}}}