{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:07:29Z","timestamp":1761919649766},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Chronic viral infections lead to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell exhaustion, characterized by impaired cytokine secretion. The immune\u2010regulatory cytokine <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 promotes chronicity of infection with lymphocytic choriomeningitis virus (<jats:styled-content style=\"fixed-case\">LCMV) C<\/jats:styled-content>lone 13, as absence of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 or blocking of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> during early <jats:styled-content style=\"fixed-case\">LCMV C<\/jats:styled-content>lone 13 infection results in viral clearance. Thus, treatment of humans suffering from chronic viral infections with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 neutralizing or <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content> blocking antibodies was proposed to boost virus\u2010specific <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell responses to enhance control or even clear the viral infection. Here we demonstrate that although <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells can produce elevated levels of cytokines in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010<jats:sup>\u2212\/\u2212<\/jats:sup> mice early after infection compared with <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010<jats:sup>\u2212\/\u2212<\/jats:sup> mice cannot clear an infection with the quicker replicating <jats:styled-content style=\"fixed-case\">LCMV<\/jats:styled-content> strain <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ocile, eventually resulting in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell exhaustion. These data suggest that the success of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 blockade to control chronic viral infections may critically depend on the virulence of the infecting strain.<\/jats:p>","DOI":"10.1002\/eji.201242887","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T14:16:46Z","timestamp":1356531406000},"page":"649-654","source":"Crossref","is-referenced-by-count":23,"title":["Reversal of chronic to resolved infection by <scp>IL<\/scp>\u201010 blockade is <scp>LCMV<\/scp> strain dependent"],"prefix":"10.1002","volume":"43","author":[{"given":"Kirsten","family":"Richter","sequence":"first","affiliation":[{"name":"Institute of Microbiology ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Perriard","sequence":"additional","affiliation":[{"name":"Institute of Microbiology ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Oxenius","sequence":"additional","affiliation":[{"name":"Institute of Microbiology ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940102"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1492"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061462"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117031"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.5.1085"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.06.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-2-381"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142275"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809818106"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914500107"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1128\/jvi.68.7.4700-4704.1994","article-title":"Enhanced establishment of a virus carrier state in adult CD4+ \n                  T\u2010cell\u2010deficient mice","volume":"68","author":"Battegay M.","year":"1994","journal-title":"J. Virol."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.1.448-457.2001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.2.1059-1070.1995"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011998107"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-8-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp107"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201242887","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201242887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T04:03:46Z","timestamp":1696651426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201242887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,25]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/eji.201242887"],"URL":"https:\/\/doi.org\/10.1002\/eji.201242887","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,25]]}}}