{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:34:36Z","timestamp":1776263676735,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>IL\u201010, a cytokine with pleiotropic functions is produced by many different cells. Although IL\u201010 may be crucial for initiating protective Th2 responses to helminth infection, it may also function as a suppressive cytokine preventing immune pathology or even contributing to helminth\u2010induced immune evasion. Here, we show that B cells and T\u00a0cells produce IL\u201010 during murine <jats:italic>Litomosoides sigmodontis<\/jats:italic> infection. IL\u201010\u2010deficient mice produced increased amounts of <jats:italic>L. sigmodontis<\/jats:italic>\u2010specific IFN\u2010\u03b3 and IL\u201013 suggesting a suppressive role for IL\u201010 in the initiation of the T\u2010cell response to infection. Using cell type\u2010specific IL\u201010\u2010deficient mice, we dissected different functions of T\u2010cell\u2010 and B\u2010cell\u2010derived IL\u201010. <jats:italic>Litomosoides sigmodontis<\/jats:italic>\u2010specific IFN\u2010\u03b3, IL\u20105, and IL\u201013 production increased in the absence of T\u2010cell\u2010derived IL\u201010 at early and late time points of infection. In contrast, B\u2010cell\u2010specific IL\u201010 deficiency did not lead to significant changes in <jats:italic>L. sigmodontis<\/jats:italic>\u2010specific cytokine production compared to WT mice. Our results suggest that the initiation of Ag\u2010specific cellular responses during <jats:italic>L. sigmodontis<\/jats:italic> infection is suppressed by T\u2010cell\u2010derived IL\u201010 and not by B\u2010cell\u2010derived IL\u201010.<\/jats:p>","DOI":"10.1002\/eji.201242929","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T07:53:49Z","timestamp":1364284429000},"page":"1799-1805","source":"Crossref","is-referenced-by-count":18,"title":["T\u2010cell\u2010derived, but not B\u2010cell\u2010derived, IL\u201010 suppresses antigen\u2010specific T\u2010cell responses in <i>Litomosoides sigmodontis<\/i>\u2010infected mice"],"prefix":"10.1002","volume":"43","author":[{"given":"Irma","family":"Haben","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Specht","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Roers","sequence":"additional","affiliation":[{"name":"Institute for Immunology Technical University Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minka","family":"Breloer","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000217"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(00)01738-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1128\/iai.65.6.2457-2461.1997","article-title":"Infection of BALB\/c mice with the filarial nematode Litomosoides sigmodontis: role of CD4+ T cells in controlling larval development","volume":"65","author":"Al\u2010Qaoud K. 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