{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:23:32Z","timestamp":1792718612071,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>\n                    Natural killer (\n                    <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\n                    ) cells are key components of the immune system involved in several immune reactions, including the clearance of intracellular pathogens. When activated,\n                    <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\n                    cells rapidly secrete particular cytokines that activate innate immunity and facilitate development of adaptive responses. Conflicting reports on the role of\n                    <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\n                    cells during infection by\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      isteria monocytogenes\n                    <\/jats:italic>\n                    can be found in the literature. Here, we demonstrate that during lethal infection by\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                    <\/jats:italic>\n                    .\n                    <jats:italic>monocytogenes<\/jats:italic>\n                    , activation of\n                    <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\n                    cells via the costimulatory molecule\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    27 leads to excessive\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010\u03b3 production. This impairs innate anti\u2010bacterial host defenses by inducing downregulation of\n                    <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>\n                    2 on granulocytes and consequently inhibiting their recruitment to the sites of infection. The use of antibodies to block\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    27 signaling or to deplete\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010\u03b3 was sufficient to rescue mice from lethal challenge by\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      . monocytogenes\n                    <\/jats:italic>\n                    . Our findings contribute to a better understanding of the importance of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    27 signaling in activation of\n                    <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\n                    cells and should provide new ways of interfering with infections.\n                  <\/jats:p>","DOI":"10.1002\/eji.201242937","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T02:52:47Z","timestamp":1372733567000},"page":"2626-2637","source":"Crossref","is-referenced-by-count":26,"title":["<scp>IFN<\/scp>\n                    \u2010\u03b3 production by\n                    <scp>CD<\/scp>\n                    27\n                    <sup>+<\/sup>\n                    <scp>NK<\/scp>\n                    cells exacerbates\n                    <i>\n                      <scp>L<\/scp>\n                      isteria monocytogenes\n                    <\/i>\n                    infection in mice by inhibiting granulocyte mobilization"],"prefix":"10.1002","volume":"43","author":[{"given":"Nuno","family":"Viegas","sequence":"first","affiliation":[{"name":"Molecular Immunology Helmholtz Centre for Infection Research, HZI  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Andzinski","sequence":"additional","affiliation":[{"name":"Molecular Immunology Helmholtz Centre for Infection Research, HZI  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Fang","family":"Wu","sequence":"additional","affiliation":[{"name":"Molecular Immunology Helmholtz Centre for Infection Research, HZI  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronja\u2010Melinda","family":"Komoll","sequence":"additional","affiliation":[{"name":"Molecular Immunology Helmholtz Centre for Infection Research, HZI  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Gekara","sequence":"additional","affiliation":[{"name":"Molecular Immunology Helmholtz Centre for Infection Research, HZI  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt E.","family":"Dittmar","sequence":"additional","affiliation":[{"name":"Department of Gene Regulation and Differentiation Helmholtz Centre for Infection Research, HZI  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Weiss","sequence":"additional","affiliation":[{"name":"Molecular Immunology Helmholtz Centre for Infection Research, HZI  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"Jablonska","sequence":"additional","affiliation":[{"name":"Molecular Immunology Helmholtz Centre for Infection Research, HZI  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830050209"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.4049\/jimmunol.121.5.1631","article-title":"Mouse natural killer cells: induction specificity, and function","volume":"121","author":"Welsh R. M.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-077438"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.05.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00101"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.4049\/jimmunol.153.4.1421","article-title":"Role of CD27 in T cell immune response. Analysis by recombinant soluble CD27","volume":"153","author":"Agematsu K.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1184"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1517"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00454.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02657.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2004.02.006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2276"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030630"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.189"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1138"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(07)96002-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.9.2892-2900.1991"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1128\/iai.64.5.1744-1749.1996","article-title":"Control of natural killer cell\u2010mediated innate resistance against the intracellular pathogen \n                     Listeria monocytogenes by gamma\/delta T lymphocytes","volume":"64","author":"Ladel C. H.","year":"1996","journal-title":"Infect. Immun."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1751"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00311-06"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.4049\/jimmunol.152.4.1873","article-title":"Role of NK1.1+ cells in experimental listeriosis. NK1+ cells are early IFN\u2010gamma producers but impair resistance to \n                     Listeria monocytogenes infection","volume":"152","author":"Teixeira H. C.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_7_23_1","first-page":"106","article-title":"Analysis of the role of natural killer cells in \n                     Listeria monocytogenes infection: relation between natural killer cells and T\u2010cell receptor gamma delta T cells in the host defence mechanism at the early stage of infection","volume":"82","author":"Takada H.","year":"1994","journal-title":"Immunology"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.125311"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.02.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115742"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200423594"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1309"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1669"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838718"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00443-06"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.01033.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1461"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.259"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.661"},{"key":"e_1_2_7_36_1","first-page":"1122","article-title":"Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor\u2010related apoptosis\u2010inducing ligand (TRAIL) but reveals that a lack of membrane TR1\/TR2 also contributes to TRAIL resistance in NB","volume":"63","author":"Yang X.","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41649"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03367.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60588"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1581"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.1741"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.563"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00361-8"},{"key":"e_1_2_7_44_1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.4049\/jimmunol.139.4.1104","article-title":"A T cell\u2010independent mechanism of macrophage activation by interferon\u2010gamma","volume":"139","author":"Bancroft G. J.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1765"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01849.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.09.017"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181818466"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900196106"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1997.0169"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8036519"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7667641"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90163-9"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.07.012"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101721"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041363"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.06.012"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1086\/428501"},{"key":"e_1_2_7_59_1","first-page":"335","article-title":"Enhanced splenic bacterial clearance and neutrophilia in anti\u2010NK1.1\u2010treated mice infected with \n                     Pseudomonas aeruginosa","volume":"11","author":"Newton D. W.","year":"1992","journal-title":"Nat. Immun."},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091110"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061840"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456301"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.201242937","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201242937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T12:31:16Z","timestamp":1696595476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201242937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,25]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/eji.201242937"],"URL":"https:\/\/doi.org\/10.1002\/eji.201242937","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718140569.793485749","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718140569.793485264","asserted-by":"object"}]},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,25]]}}}